Anti-PD-L2 Antibody [PDL2/1850] - BSA and Azide free
Description
Mouse monoclonal [PDL2/1850] antibody to PD-L2.
Specificity
This antibody recognizes a protein of about 31kDa, which is identified as PD-L2 (same as PDCD1LG2). Engagement of CD28 by B7-1 (CD80) or B7-2 (CD86) in the presence of antigen promotes T cell proliferation, cytokine production, differentiation of effector T cells and the induction of Bcl-x, a promoter of T cell survival. Conversely, engagement of CTLA4 by B7-1 or B7-2 may inhibit proliferation and IL-2 production. PD-L2 does not bind CD28, cytotoxic T lymphocyte A4 or ICOS (inducible co-stimulator). The constitutive expression of PD-L1 and PD-L2 on parenchymal cells of heart, lung and kidney suggests that the Pdcd-1-Pdcd-L system could provide unique negative signaling to help prevent autoimmune disease.
Applications
Flow Cytometry
Dilutions
Flow Cytometry: 1-2 µg/million cells
Reactivity
Human
Immunogen
Recombinant fragment, around amino acids 27-220, of human PD-L2 protein. The exact sequence is proprietary.
Host
Mouse
Clonality
Monoclonal
Clone ID
PDL2/1850
Isotype
IgG1
Light Chains
kappa
Conjugate
Unconjugated
Purification
Protein A/G chromatography.
Concentration
1 mg/ml
Molecular Weight
31 kDa
Product Form
Liquid
Formulation
Supplied in 10mM Phosphate Buffered Saline; without Sodium Azide and carrier free.
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
SDS-PAGE analysis of Anti-PD-L2 Antibody [PDL2/1850] under non-reduced and reduced conditions; showing intact IgG and intact heavy and light chains, respectively. SDS-PAGE analysis confirms the integrity and purity of the antibody.
Flow cytometric analysis of Jurkat cells using Anti-PD-L2 Antibody [PDL2/1850] followed by Goat Anti-Mouse IgG (CF® 488) (Blue). Isotype Control (Red).
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