Anti-PD-L2 Antibody [PDL2/1850] (A250389)

Anti-PD-L2 Antibody [PDL2/1850]

Mouse monoclonal [PDL2/1850] antibody to PD-L2.

This antibody recognizes a protein of about 31kDa, which is identified as PD-L2 (same as PDCD1LG2). Engagement of CD28 by B7-1 (CD80) or B7-2 (CD86) in the presence of antigen promotes T cell proliferation, cytokine production, differentiation of effector T cells and the induction of Bcl-x, a promoter of T cell survival. Conversely, engagement of CTLA4 by B7-1 or B7-2 may inhibit proliferation and IL-2 production. PD-L2 does not bind CD28, cytotoxic T lymphocyte A4 or ICOS (inducible co-stimulator). The constitutive expression of PD-L1 and PD-L2 on parenchymal cells of heart, lung and kidney suggests that the Pdcd-1-Pdcd-L system could provide unique negative signaling to help prevent autoimmune disease.

Flow Cytometry: 1-2 µg/million cells

Human

Recombinant fragment, around amino acids 27-220, of human PD-L2 protein. The exact sequence is proprietary.

Mouse

Monoclonal

PDL2/1850

IgG1

kappa

Protein A/G chromatography.

200 µg/ml

31 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

This monoclonal antibody is also available in a different formulation without BSA and Sodium Azide - Anti-PD-L2 Antibody [PDL2/1850] - BSA and Azide free (A253569).

B7-DC, B7DC, Butyrophilin B7-DC, CD273, PD-1 ligand 2, PDCD1 ligand 2, PDCD1L2, PDCD1LG2, PDL2, Programmed cell death 1 ligand 2, Programmed death ligand 2