VLDLR (very low density lipoprotein receptor) is a member of the LDL receptor gene family, which includes LDL receptor, LRP, megalin, VLDLR and ApoER2. The LDL receptor family is characterized by a cluster of cysteine-rich class A repeats, epidermal growth factor (EGF)-like repeats, YWTD repeats and an O-linked sugar domain. VLDLR associates with RAP (receptor associated protein) during receptor folding, and RAP facilitates the secretion of the extracellular region of VLDLR. VLDLR is thought to mediate the interaction of extracellular Reelin and cytosolic mDab1 (mammalian disabled protein), which activates a tyrosine kinase. This pathway regulates the migration of neurons along the radial glial fiber network during brain development.

Applications

ELISA

Reactivity

Human, Rat

Immunogen

Recombinant C terminal fragment of human VLDLR protein.

Host

Rabbit

Clonality

Monoclonal

Clone ID

VLDLR/2896R

Isotype

IgG

Conjugate

Unconjugated

Purification

Protein A/G chromatography.

Concentration

200 µg/ml

Molecular Weight

143-161 kDa

Product Form

Liquid

Formulation

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Storage

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

General Notes

This monoclonal antibody is also available in a different formulation without BSA and Sodium Azide - Anti-VLDL Receptor Antibody [VLDLR/2896R] - BSA and Azide free (A253497).

Synonyms

FLJ35024, Very low density lipoprotein receptor, Very low-density lipoprotein receptor, VLDL R, VLDL-R, VLDLR, VLDLRCH, VLDLR_HUMAN

Isotype Controls

Suitable Secondaries

See all Anti-Rabbit IgG Secondaries →

Disclaimer

This product is for research use only. It is not intended for diagnostic or therapeutic use.

Scientific Validation Data (1)

Enlarge Image

Figure 1: SDS-PAGE - Anti-VLDL Receptor Antibody [VLDLR/2896R] (A250317)

SDS-PAGE analysis of Anti-VLDL Receptor Antibody [VLDLR/2896R] under non-reduced and reduced conditions; showing intact IgG and intact heavy and light chains, respectively. SDS-PAGE analysis confirms the integrity and purity of the antibody.

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