Anti-TWEAK Antibody [C06-3C8] (A279937)

Anti-TWEAK Antibody [C06-3C8]

Mouse monoclonal [C06-3C8] antibody to TWEAK.

This antibody recognises TWEAK, a 23 kDa type II transmembrane protein belonging to the Tumour Necrosis Factor (TNF) superfamily. While TWEAK is cell surface-associated, a smaller biologically active form can also be shed into the extracellular milieu.TWEAK, expressed primarily as a soluble cytokine by infiltrating leukocytes, mediates multiple activities through its receptor FGF-inducible molecule 14 (Fn14, TNFRSF12). It is a weak inducer of apoptosis in some cell types and is involved in the induction of inflammatory cytokines. This cytokine also promotes proliferation and migration of endothelial cells and acts as a regulator of angiogenesis. As a result of its pro-angiogenic effects, the role of this pathway in tumor biology has also been discussed.

Human

E. coli derived recombinant protein corresponding to amino acids 97-249 of human TWEAK.

KGRKTRARRAIAAHYEVHPRPGQDGAQAGVDGTVSGWEEARINSSSPLRYNRQIGEFIVTRAGLYYLYCQVHFDEGKAVYLKLDLLVDGVLALRCLEEFSATAASSLGPQLRLCQVSGLLALRPGSSLRIRTLPWAHLKAAPFLTYFGLFQVH

Mouse

Monoclonal

C06-3C8

IgG1

Unconjugated

1 mg/ml

Liquid

Supplied in Phosphate Buffered Saline with <0.1% Sodium Azide.

Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.

Mouse anti Human TWEAK antibody, clone C06-3C8 recognizes TWEAK, a 23 kDa type II transmembrane protein belonging to the Tumour Necrosis Factor (TNF) superfamily. While TWEAK is cell surface-associated, a smaller biologically active form can also be shed into the extracellular milieu.TWEAK, expressed primarily as a soluble cytokine by infiltrating leukocytes, mediates multiple activities through its receptor FGF-inducible molecule 14 (Fn14, TNFRSF12). It is a weak inducer of apoptosis in some cell types and is involved in the induction of inflammatory cytokines (Chicheportiche et al. 1997). This cytokine also promotes proliferation and migration of endothelial cells and acts as a regulator of angiogenesis. As a result of its pro-angiogenic effects, the role of this pathway in tumor biology has also been discussed (Michaelson & Burkly, 2009).

APO 3 ligand, APO 3L, APO3 ligand, APO3/DR3 ligand, APO3L, DR3LG, MGC129581, MGC20669, secreted form, TNF-related weak inducer of apoptosis, TNF12_HUMAN, TNFSF 12, Tnfsf12, TNFSF12 protein, Tumor necrosis factor (ligand) superfamily member 12, Tumor necrosis factor ligand superfamily member 12, Tumor necrosis factor superfamily member 12, UNQ181/PRO207