Mouse monoclonal [TRM-17 (Mab17)] antibody to Tropomodulin 1.
Specificity
This antibody recognises chicken tropomodulin 1, otherwise known as erythrocyte tropomodulin or E-Tmod, an evolutionary very highly conserved cytoskeletal protein. Tropomodulin 1 is a sarcomeric protein highly expressed by erythrocytes, heart and skeletal muscle, which binds to and caps pointed ends of actin filaments to prevent thin filament elongation. The binding of the N-terminal region of Tmod1 with the actin-binding protein tropomyosin blocks the elongation and depolymerization of actin filaments, contributing to the geometry of the membrane skeleton.recognises an epitope between amino acid residues 6-57 within the N-terminal region of tropomodulin 1 and inhibits the binding of Tmod1 to tropomyosin.
Applications
WB, ELISA, Functional Assays, IF
Reactivity
Chicken, Birds, Mammals, Fish, Insect, Reptile
Immunogen
Recombinant Chicken tropomodulin 1.
Host
Mouse
Clonality
Monoclonal
Clone ID
TRM-17 (Mab17)
Isotype
IgG1
Conjugate
Unconjugated
Purification
Protein A affinity chromatography of tissue culture supernatant.
Concentration
1 mg/ml
Molecular Weight
Approximately 40 kDa in chick heart lysates.
Product Form
Liquid
Formulation
Supplied in Phosphate Buffered Saline with <0.1% Sodium Azide.
Storage
Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.
General Notes
Mouse anti Tropomodulin 1 (N-Terminal) antibody, clone TRM-17 recognizes chicken tropomodulin 1, otherwise known as erythrocyte tropomodulin or E-Tmod, an evolutionary very highly conserved cytoskeletal protein .Tropomodulin 1 is a sarcomeric protein highly expressed by erythrocytes, heart and skeletal muscle, which binds to and caps pointed ends of actin filaments to prevent thin filament elongation. The binding of the N-terminal region of Tmod1 with the actin-binding protein tropomyosin blocks the elongation and depolymerization of actin filaments, contributing to the geometry of the membrane skeleton.Mouse anti Tropomodulin 1 (N-Terminal) antibody, clone TRM-17 recognizes an epitope between amino acid residues 6-57 within the N-terminal (NT) region of tropomodulin 1 and inhibits the binding of Tmod1 to tropomyosin.
Synonyms
D9S57E, E Tmod, E tropomodulin, E-Tmod, Erythrocyte tropomodulin, ETMOD, MGC124125, MGC124126, OTTHUMP00000021743, TMOD, Tmod1, TMOD1 protein, TMOD1_HUMAN, Tropomodulin-1
