Anti-Tissue Plasminogen Activator Antibody [D12-9A7] (Biotin) (A280207)

Anti-Tissue Plasminogen Activator Antibody [D12-9A7] (Biotin)

Mouse monoclonal [D12-9A7] antibody to Tissue Plasminogen Activator (Biotin).

This antibody recognises tissue type plasminogen activator (tPA) also known as PLAT. tPA is a serine protease that in the intravascular space, catalyzes the conversion of plasminogen to plasmin. tPA is expressed in various cell types including endothelial cells, glial cells and neurons. Within the brain tPA plays a role in synaptic plasticity, detection and adaptation to metabolic stress, modulation of the blood-brain barrier permeability and remodeling of the extracellular matrix. The biotinylated Mouse anti Human tPA antibody, clone D12-9A7 (MCA6283B) can be used as a detection antibody in a sandwich ELISA with the purified Mouse anti Human tPA antibody, clone D11-7G8 (MCA6282GA) as the capture antibody.

ELISA: 1 µg/ml

Human

Purified native human tPA.

Mouse

Monoclonal

D12-9A7

IgG1

Protein G affinity chromatography of tissue culture supernatant.

100 µg/ml

Liquid

Supplied in Phosphate Buffered Saline with 1% BSA and 0.09% Sodium Azide.

Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended. This product is photosensitive and should be protected from light.

Mouse anti Human tPA antibody, clone D12-9A7, recognizes tissue type plasminogen activator (tPA) also known as PLAT. tPA is a serine protease that in the intravascular space, catalyzes the conversion of plasminogen to plasmin. tPA is expressed in various cell types including endothelial cells, glial cells and neurons. Within the brain tPA plays a role in synaptic plasticity, detection and adaptation to metabolic stress, modulation of the blood-brain barrier permeability and remodeling of the extracellular matrix (Jeanneret & Yepes 2017).The biotinylated Mouse anti Human tPA antibody, clone D12-9A7 (MCA6283B) can be used as a detection antibody in a sandwich ELISA with the purified Mouse anti Human tPA antibody, clone D11-7G8 (MCA6282GA) as the capture antibody.

Alteplase, Endothelial plasminogen activator inhibitor, PAI, PAI 1, PAI1, PAI1 + tPA, PLANH1, Plasminogen activator inhibitor 1, Plasminogen activator tissue, Plasminogen activator tissue type, PLAT, Reteplase, Serine (or cysteine) proteinase inhibitor clade E (nexin plasminogen activator inhibitor type 1) member 1, Serpin E1, Serpin peptidase inhibitor clade E (nexin plasminogen activator inhibitor type 1) member 1, SERPINE1, T PA, T plasminogen activator, Tissue type plasminogen activator, TPA

This product is for research use only. It is not intended for diagnostic or therapeutic use.