Anti-TIMP1 Antibody [TIMP1/2605] - BSA and Azide free (A317115)

Anti-TIMP1 Antibody [TIMP1/2605] - BSA and Azide free

Mouse monoclonal [TIMP1/2605] antibody to TIMP1.

TIMP-1, TIMP-2, TIMP-3 and TIMP-4 (for tissue inhibitor of metalloproteinases -1, -2, -3 and -4) complex with metalloproteinases such as collagenases, gelatinases and stromelysins, resulting in irreversible inactivation of the metalloproteinase. TIMP-1 is identical to EPA (erythroid-potentiation activity). PTH has been shown to be a regulator of TIMP-2 in osteoblastic cells. TIMP-3 may be involved in regulating trophoblastic invasion of the uterus as well as in regulating remodeling of the extracellular matrix during the folding of epithelia, and in the formation, branching and expansion of epithelial tubes. TIMP-4 is most highly expressed in heart tissues. Studies have demonstrated that TIMP1 is useful as a biomarker for early detection of colorectal cancer, outperforming CEA. Additionally, TIMP1 studies have demonstrated its role in CRC tumorigenesis, as well as observing its overexpression in metastatic lymph nodes.

ELISA, IHC-P

293 cells. Human colon carcinoma.

ELISA: 2-4 µg/ml for coating, IHC: 1-2 µg/ml

Human

Recombinant human TIMP1 protein fragment (around Amino Acids 1-200). The exact sequence is proprietary.

Mouse

Monoclonal

TIMP1/2605

kappa

Protein A chromatography.

1 mg/ml

23 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline; without Sodium Azide and carrier free.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

CLGI, Collagenase inhibitor, EPA, Erythroid-potentiating activity, Fibroblast collagenase inhibitor, Metalloproteinase inhibitor 1, TIMP, TIMP-1, Tissue inhibitor of metalloproteinases 1