Anti-TIA1 Antibody [TIA1/1313] (A250129)

Mouse monoclonal [TIA1/1313] antibody to TIA1 for Flow Cytometry, IF and WB.

Alternative Formats and ConjugatesAlternative Formats

Freight Charges
Lead Time
4-6 Business Days
Telephone
+1 (314) 370-6046
Mon - Fri, 8am - 4pm AST
Email
orders@antibodies.com
Name
Anti-TIA1 Antibody [TIA1/1313]
Description
Mouse monoclonal [TIA1/1313] antibody to TIA1.
Specificity
TIA-1 (T-cell intracytoplasmic antigen) is a cytoplasmic granule-associated protein, expressed in lymphocytes processing cytolytic potential. TIA-1 is a member of an RNA-binding protein family and possesses nucleolytic activity against cytotoxic lymphocyte (CTL) target cells. It has been suggested that this protein may be involved in the induction of apoptosis as it preferentially recognizes poly(A) homopolymers and induces DNA fragmentation in CTL targets. The major granule-associated species is a 15kDa protein thought to be derived from the carboxyl terminus of the 40kDa product by proteolytic processing. TIA1 antibody labels cytotoxic T cells and natural killer cells (NK cells). It is also expressed in T-cell lymphoma, large granular lymphocyte (LGL) leukemia and hairy cell leukemia. TIA1 expression in T-cell malignancies may help in differentiating LGL leukemia (high expression) from T-cell lymphocytosis and other T-cell diseases (low expression). TIA1 may also be used to label tumor-infiltrating lymphocytes in the study of immune response to malignancies.
Applications
Flow Cytometry, IF, WB
Dilutions
Flow Cytometry: 0.5-1 µg/million cells, IF: 1-2 µg/ml, WB: 1-2 µg/ml
Reactivity
Human
Immunogen
Recombinant fragment, around amino acids 279-380, of human TIA1 protein.
Host
Mouse
Clonality
Monoclonal
Clone ID
TIA1/1313
Isotype
IgG2b
Light Chains
kappa
Conjugate

Unconjugated

Purification
Protein A chromatography.
Concentration
200 µg/ml
Molecular Weight
40 kDa
Product Form
Liquid
Formulation
Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
General Notes
This monoclonal antibody is also available in a different formulation without BSA and Sodium Azide - Anti-TIA1 Antibody [TIA1/1313] - BSA and Azide free (A253309).
Synonyms
Cytotoxic granule associated RNA binding protein, Cytotoxic granule associated RNA binding protein 1, mTIA-1, Nucleolysin TIA 1 isoform p40, Nucleolysin TIA-1 isoform p40, Nucleolysin TIA1 isoform p40, p40 TIA 1, p40-TIA-1, p40-TIA-1 (containing p15-TIA-1), RNA binding protein TIA 1, RNA binding protein TIA1, RNA-binding protein TIA-1, T-cell-restricted intracellular antigen-1, Tia, TIA 1, TIA 1 cytotoxic granule associated RNA binding protein, TIA-1, TIA1 cytotoxic granule associated RNA binding protein, TIA1 cytotoxic granule associated RNA binding protein like 1, TIA1 protein, TIA1_HUMAN, TIAL1, TIAR, WDM
Disclaimer
This product is for research use only. It is not intended for diagnostic or therapeutic use.
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