Recombinant Anti-Thymidine Phosphorylase Antibody [TYMP/2890R] - BSA and Azide free (A251567)

Recombinant rabbit monoclonal [TYMP/2890R] antibody to Thymidine Phosphorylase for IHC-P.

Alternative Formats and ConjugatesAlternative Formats

Freight Charges
Lead Time
4-6 Business Days
Telephone
+1 (314) 370-6046
Mon - Fri, 8am - 4pm AST
Email
orders@antibodies.com
Name
Anti-Thymidine Phosphorylase Antibody [TYMP/2890R] - BSA and Azide free
Description
Recombinant rabbit monoclonal [TYMP/2890R] antibody to Thymidine Phosphorylase.
Specificity
This antibody recognizes a protein (amino acid 482) of 55kDa (in vivo 110kDa homodimer), identified as platelet-derived endothelial growth factor (PD-ECGF), same as thymidine phosphorylase (TP) or gliostatin. In the presence of inorganic orthophosphate, it catalyzes the reversible phospholytic cleavage of thymidine and deoxyuridine to their corresponding bases and 2-deoxyribose-1-phosphate. It is both chemotactic and mitogenic for endothelial cells and a non-heparin binding angiogenic factor present in platelets. Its enzymatic activity is crucial for angiogenic activity (metabolite is angiogenic). Higher levels of serum TP/PD-ECGF are observed in cancer patients. It is also involved in transformation of fluoropyrimidines, cytotoxic agents used in the treatment of a variety of malignancies, into active cytotoxic metabolites (e.g. 5'-deoxy-5-fluorouridine to 5-FU). High intra-cellular levels of TP/PD-ECGF are associated with increased chemosensitivity to such antimetabolites.
Applications
IHC-P
Dilutions
IHC-P: 1-2 µg/ml
Reactivity
Human, Mouse, Rat
Immunogen
Recombinant full-length human Thymidine Phosphorylase protein.
Host
Rabbit
Clonality
Monoclonal
Clone ID
TYMP/2890R
Isotype
IgG
Conjugate

Unconjugated

Purification
Protein A/G chromatography.
Concentration
1 mg/ml
Molecular Weight
55 kDa
Product Form
Liquid
Formulation
Supplied in 10mM Phosphate Buffered Saline; without Sodium Azide and carrier free.
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
General Notes
This monoclonal antibody is also available in a different formulation with BSA and Sodium Azide - Anti-Thymidine Phosphorylase Antibody [TYMP/2890R] (A248385).
Synonyms
ECGF, ECGF 1, ECGF1, Endothelial cell growth factor 1, Endothelial cell growth factor 1 platelet derived, Endothelial cell growth factor, platelet-derived, Gliostatin, hPD ECGF, MEDPS1, MNGIE, MTDPS1, PD ECGF, PD-ECGF, PDECGF, PDEGF, Platelet derived endothelial cell growth factor, Platelet derived endothelial growth factor, Platelet-derived endothelial cell growth factor, TdRPase, TP, Tymp, TYPH_HUMAN
Disclaimer
This product is for research use only. It is not intended for diagnostic or therapeutic use.
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