Anti-TCF7 Antibody [TCF7/7631] (A315713)

Anti-TCF7 Antibody [TCF7/7631]

Mouse monoclonal [TCF7/7631] antibody to TCF7.

Transcriptional activator involved in T-cell lymphocyte differentiation. Necessary for the survival of CD4(+) CD8(+) immature thymocytes. Isoforms lacking the N-terminal CTNNB1 binding domain cannot fulfill this role. Binds to the T-lymphocyte-specific enhancer element (5) found in the promoter of the CD3E gene. Represses expression of the T-cell receptor gamma gene in alpha-beta T-cell lineages (By similarity). Required for the development of natural killer receptor-positive lymphoid tissue inducer T-cells (By similarity). TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by TCF7 and CTNNB1.May also act as feedback transcriptional repressor of CTNNB1 and TCF7L2 target genes.

Human spleen, lung, adrenal gland or colon.

IHC: 1-2 µg/ml

Human

Recombinant fragment (around Amino Acids 200-400) of human TCF7 protein. The exact sequence is proprietary.

Mouse

Monoclonal

TCF7/7631

kappa

Protein A/G chromatography.

200 µg/ml

41.6 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

T-cell factor 1, T-cell-specific transcription factor 1, TCF-1, TCF-7, TCF1, Transcription factor 7