Synthetic nanodiscs offer a stable and biologically relevant environment that closely mimics cell membranes and enables full-length transmembrane human GPCR GPR124 protein to be purified and analysed in vitro.
Expression System
HEK293 cells
Nature
Synthetic
Protein Species
Human
Protein Length
Full length protein.
Molecular Weight
Full length human GPCR GPR124 protein has a MW of 142.6 kDa.
Conjugate
Unconjugated
Product Form
Lyophilized
Concentration
Reconstitution dependent.
Formulation
Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% - 8% trehalose is added as protectants before lyophilization.
Storage
Shipped at 4°C. Lyophilized: Store at -20°C to -80°C. Reconstituted: Aliquot and store at -80°C. Product is stable for one year. Avoid freeze/thaw cycles.
Synonyms
DKFZp434C211, DKFZp434J0911, FLJ14390, G protein coupled receptor 124, G-protein coupled receptor 124, GP124_HUMAN, GPR 124, Gpr124, KIAA1531, TEM 5, TEM5, Tumor endothelial marker 5, Tumor endothelial marker 5 precursor
Disclaimer
This product is for research use only. It is not intended for diagnostic or therapeutic use.
Figure 1: Synthetic Nanodisc Human GPCR GPR124 Protein (A325158)
Diagram showing how synthetic nanodiscs containing full-length multi-pass transmembrane proteins in a phospholipid bilayer are generated from native cell membranes.
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