Recombinant rabbit monoclonal [SYP/7976R] antibody to Synaptophysin.
Specificity
This recombinant rabbit monoclonal antibody recognizes a protein of 38kDa that is identified as synaptophysin. It is an N-glycosylated integral membrane protein found in neurons and endocrine cells. Synaptophysin contains four transmembrane domains and may function as a gap junction-like channel. This antibody identifies normal neuroendocrine cells and neuroendocrine neoplasms. Diffuse, finely granular, cytoplasmic staining is observed, which probably correlates with the distribution of the antigen within neurosecretory vesicles. Synaptophysin is an independent, broad-range marker of neural and neuroendocrine differentiation.
Applications
IHC-P
Positive Control
HepG2, HeLa or Y79 cells. Human pancreas, cerebellum or pheochromocytoma.
Dilutions
IHC: 1-2 µg/ml
Reactivity
Human
Immunogen
Recombinant fragment (around Amino Acids 274-313) of human Synaptophysin (SYP) protein. The exact sequence is proprietary.
Host
Rabbit
Clonality
Monoclonal
Clone ID
SYP/7976R
Isotype
IgG
Light Chains
kappa
Conjugate
Unconjugated
Purification
Protein A/G chromatography.
Concentration
200 µg/ml
Molecular Weight
38 kDa
Product Form
Liquid
Formulation
Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Synonyms
Major synaptic vesicle protein p38, MRX96, MRXSYP, Syn p38, Syp, SYPH, SYPH_HUMAN, SypI
This product is for research use only. It is not intended for diagnostic or therapeutic use.
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