Anti-Syk Antibody [SYK-01] (A281797)

Anti-Syk Antibody [SYK-01]

Mouse monoclonal [SYK-01] antibody to Syk.

This antibody recognises protein tyrosine kinase p72syk (syk), a ~72kDa non-receptor tyrosine kinase, critical for immunoreceptor signaling in haematopoietic cells, but also expressed by nonhaematopoietic cells, including fibroblasts, endothelial cells and hepatocytes.Syk plays an important role in mast cell response, initiated by the aggregation of the IgE high affinity receptor Fc epsilon R1. Phosphorylation of ITAMs within Fc receptor R1 by another tyrosine kinase lyn, results in the recruitment of syk, which is then responsible for the further phosphorylation of numerous target proteins within many different signal transduction pathways.Syk also plays a major role in B cell receptor-mediated apoptosis, proliferation and haematopoiesis. Syk associates with protein kinase C alpha during platelet activation.

WB, IP

Human, Mouse, Rat

Recombinant fragment corresponding to amino acids 5 - 360 of human syk.

GMADSANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRKAHHYTIERELNGTYAIAGGRTHASPADLCHYHSQESDGLVCLLKKPFNRPQGVQPKTGPFEDLKENLIREYVKQTWNLQGQALEQAIISQKPQLEKLIATTAHEKMPWFHGKISREESEQIVLIGSKTNGKFLIRARDNNGSYALCLLHEGKVLHYRIDKDKTGKLSIPEGKKFDTLWQLVEHYSYKADGLLRVLTVPCQKIGTQGNVNFGGRPQLPGSHPATWSAGGIISRIKSYSFPKPGHRKSSPAQGNRQESTVSFNPYEPELAPWAADKGPQREALPMDTEVYESPYADPEEIRP

Mouse

Monoclonal

SYK-01

IgG1

Unconjugated

1 mg/ml

Approximately 72 kDa in Ramos & RBL cell lysates.

Liquid

Supplied in Phosphate Buffered Saline with <0.1% Sodium Azide.

Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.

Mouse anti Human Syk antibody, clone SYK-01 recognizes protein tyrosine kinase p72syk (syk), a ~72kDa non-receptor tyrosine kinase, critical for immunoreceptor signaling in haematopoietic cells, but also expressed by nonhaematopoietic cells, including fibroblasts, endothelial cells and hepatocytes.Syk plays an important role in mast cell response, initiated by the aggregation of the IgE high affinity receptor Fc epsilon R1. Phosphorylation of ITAMs within Fc receptor R1 by another tyrosine kinase lyn, results in the recruitment of syk, which is then responsible for the further phosphorylation of numerous target proteins within many different signal transduction pathways.Syk also plays a major role in B cell receptor-mediated apoptosis, proliferation and haematopoiesis. Syk associates with protein kinase C alpha during platelet activation.

EC 2.7.10.2, kinase Syk, KSYK, KSYK_HUMAN, p72-Syk, p72syk, Spleen tyrosine kinase, Tyrosine protein kinase SYK, Tyrosine-protein kinase SYK