Recombinant Anti-STAT6 Antibody [STAT6/7774R] (A315676)

Anti-STAT6 Antibody [STAT6/7774R]

Recombinant rabbit monoclonal [STAT6/7774R] antibody to STAT6.

STAT6 is a transcription factor in the Jak/STAT signal transduction pathway responsible for mediating IL-4 immune signaling. STAT6 was recently suggested to be a reliable marker to distinguish solitary fibrous tumors from other soft tissue neoplasms. Gene fusions are common in solitary fibrous tumors. Recent next generation sequencing studies demonstrated the presence of a NAB2-STAT6 fusion, formed by an intrachromosomal inversion fusing two neighboring genes on chromosome 12q13, in 55-100% of solitary fibrous tumors, regardless of tumor morphology or anatomical site. By immunohistochemistry, nuclear STAT6 expression can discriminate solitary fibrous tumors from its morphological mimics in the meninges, including meningioma, glioblastoma, gliosarcoma, haemangioblastoma, schwannoma and haemangioma. A recent study by Cheah, et al. using the rabbit monoclonal STAT6 antibody (Clone YE361) observed expression in all solitary fibrous tumors (54/54) tested, regardless of histology, anatomical site or CD34 status. Morphological mimics of solitary fibrous tumors were negative, demonstrating 100% specificity.

HeLa or HepG2 cells. Human kidney.

IHC: 1-2 µg/ml

Human

Recombinant fragment (around Amino Acids 647-847) of human STAT6 protein. The exact sequence is proprietary.

Rabbit

Monoclonal

STAT6/7774R

kappa

Unconjugated

Protein A/G chromatography.

200 µg/ml

119 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

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