Anti-StAR Antibody [STAR/3976] (A315674)

Anti-StAR Antibody [STAR/3976]

Mouse monoclonal [STAR/3976] antibody to StAR.

Steroidogenic Acute Regulatory Protein (STAR) controls the rate-limiting step of steroidegenesis by translocating cholesterol from the outer mitochondrial membrane to the inner membrane where it is later cleaved to pregnenolone.It is primarily present in steroid-producing cells, including Leydig cells in the testis, theca cells and luteal cells in the ovary and adrenal cells in the adrenal cortex. Due to low levels of pregnenolone, seminomas and Leydig cell tumors display no specific STAR staining. Therefore, STAR antibody may assist in differentiating sex cord stromal tumors (SCST), seminomas and embryonal carcinomas.

K-562 cells. Human adrenal or testicular carcinoma.

IHC: 1-2 µg/ml

Human

Recombinant fragment (around Amino Acids 39-108) of human STAR protein. The exact sequence is proprietary.

Mouse

Monoclonal

STAR/3976

kappa

Protein A/G chromatography.

200 µg/ml

30 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

StARD1, START domain-containing protein 1, Steroidogenic acute regulatory protein, mitochondrial