Anti-SREBP1 Antibody [SREBP1/1578] (A250052)

Anti-SREBP1 Antibody [SREBP1/1578]

Mouse monoclonal [SREBP1/1578] antibody to SREBP1.

The low density lipoprotein (LDL) receptor mediates the endocytic uptake of cholesterol-carrying lipoproteins, thereby controlling cholesterol levels in cells and plasma. Transcription of the LDL receptor gene is controlled by a ten base pair sequence in the 5' flanking region, designated sterol regulatory element 1 (SRE-1). When cellular sterol stores are depleted, the element is activated, the gene is transcribed and the cellular uptake of LDL increases. A set of SREbinding proteins (SREBPs) have been identified, including two basic helixloop-helix-leucine zipper (bHLH-zip) transcription factors, designated SREBP-1 and SREBP-2. SREBP-1 and SREBP-2 have been shown to have the same specificity for SRE-1 in vitro and to activate the transcription of reporter genes containing SRE-1 in the same way.

Human

Recombinant full-length human SREBF1 protein.

Mouse

Monoclonal

SREBP1/1578

IgG2b

kappa

Protein A/G chromatography.

200 µg/ml

68 kDa / 125 kDa mature kDa / precursor

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

This monoclonal antibody is also available in a different formulation without BSA and Sodium Azide - Anti-SREBP1 Antibody [SREBP1/1578] - BSA and Azide free (A253232).

BHLHD1, Class D basic helix-loop-helix protein 1, SREBF1, SREBP-1, Sterol regulatory element-binding protein 1, Sterol regulatory element-binding transcription factor 1