Anti-Spastin Antibody [Sp 6C6] (A250022)

Anti-Spastin Antibody [Sp 6C6]

Mouse monoclonal [Sp 6C6] antibody to Spastin.

The AAA protein family members share an ATPase domain and have roles in various cellular processes including intracellular motility, membrane trafficking, proteolysis, protein folding and organelle biogenesis. Spastin, a member of the AAA protein family, is a 616 amino acid protein and is involved in the function or assembly of nuclear protein complexes. The Spastin protein is expressed ubiquitously and localizes to the nucleus and the cytoplasm, where it may also be involved in microtubule dynamics. Mutations in the Spastin gene (SPAST, SPG4) cause the most common form of spastic paraplegia 4, an autosomal dominant form of hereditary spastic paraplegia (HSP). HSPs comprise a group of inherited neurological disorders characterized by spastic lower extremity weakness due to a length-dependent, retrograde axonopathy of corticospinal motor neurons. SPAST-specific mutations account for approximately 40% of all autosomal dominant HSPs.

IF, WB

IF: 1-2 µg/ml, IHC: 1-2 µg/ml

Human, Mouse, Rat

Recombinant full-length human Spastin protein.

Mouse

Monoclonal

Sp 6C6

IgG2a

Unconjugated

Protein A/G chromatography.

200 µg/ml

52 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

This monoclonal antibody is also available in a different formulation without BSA and Sodium Azide - Anti-Spastin Antibody [Sp 6C6] - BSA and Azide free (A253202).

ADPSP, FSP 2, FSP2, KIAA1083, Spast, Spastic paraplegia 4, spastic paraplegia 4 (autosomal dominant; spastin), SPG 4, SPG4, SPG4 gene