Anti-SP100 Antibody [PCRP-SP100-1B9] (A277802)

Mouse monoclonal [PCRP-SP100-1B9] antibody to SP100 for ELISA, WB, IF, IP, Flow Cytometry and IHC-P.

Alternative Formats and ConjugatesAlternative Formats

Shipping Information

$40
Dispatched from St. Louis, MO.
Lead Time: 4-6 business days.
Name
Anti-SP100 Antibody [PCRP-SP100-1B9]
Description
Mouse monoclonal [PCRP-SP100-1B9] antibody to SP100.
Specificity
The human SP100 gene encodes an autoantigen that co-localizes with PML and NDP52 in distinct nuclear domains, called nuclear dots (NDs) or ND10 nuclear bodies. Papova-, adeno-, and herpesviruses begin their transcription and DNA-replication at NDs, which play a role in autoimmunity, viral infections and in the etiology of acute promyelocytic leukemia. SP-100 is an interferon inducible protein that has two splice variants. One splice variant contains a highly conserved copy of the DNA-binding high mobility group 1 protein sequence, and thus represents a novel HMG-box protein. This alternatively spliced variant of SP-100 has a unique expression and localization pattern that is distinct from the SP-100 full-length protein. The SP100 protein is covalently modified by the small ubiquitin-related protein SUMO-1. SP-100 contains a functional nuclear localization signal and an ND-targeting region, which overlaps with the SP-100 homodimerization domain.
Applications
ELISA, WB, IF, IP, Flow Cytometry, IHC-P
Dilutions
WB: 1-2 µg/ml, IF: 0.5-2 µg/ml, IP: 1-2µg / 100-500µg proteins, FC: 0.5-2 µg/million cells, IHC-P: 1-2 µg/ml
Reactivity
Human
Immunogen
Recombinant full-length human SP100 protein.
Host
Mouse
Clonality
Monoclonal
Clone ID
PCRP-SP100-1B9
Isotype
IgG2b
Conjugate

Unconjugated

Purification
Protein A/G chromatography.
Concentration
200 µg/ml
Molecular Weight
100.4 kDa
Product Form
Liquid
Formulation
Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
General Notes
This monoclonal antibody is also available in a different formulation without BSA and Sodium Azide - Anti-SP100 Antibody [PCRP-SP100-1B9] - BSA and Azide free (A278390).
Disclaimer
This product is for research use only. It is not intended for diagnostic or therapeutic use.
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