Recombinant Anti-SOX10 Antibody [rSOX10/1074] (A250017)

Anti-SOX10 Antibody [rSOX10/1074]

Recombinant mouse monoclonal [rSOX10/1074] antibody to SOX10.

SOX genes comprise a family of genes that are related to the mammalian sex-determining gene SRY. These genes similarly contain sequences that encode for the HMG-box domain, which is responsible for the sequence-specific DNA-binding activity. SOX-10 is a sensitive marker of melanoma, including conventional, spindled, and desmoplastic subtypes. It is expressed by metastatic melanomas and nodal capsular nevus in sentinel lymph nodes, but not by other lymph node components such as dendritic cells, which usually express S100 protein. Commonly used melanoma markers, such as anti-HMB-45 and anti-Melan-A, are poorly expressed in desmoplastic melanomas while SOX-10 is moderately to strongly expressed in desmoplastic melanomas. SOX-10 is considered as a very reliable marker for recognizing residual desmoplastic melanomas. In normal tissues, it is expressed in Schwann cells, melanocytes, and myoepithelial cells of salivary, bronchial and mammary glands. SOX-10 expression is also observed in mast cells.

WB, IHC-P

WB: 2-4 µg/ml, IHC-P: 1-2 µg/ml

Human, Mouse

Recombinant fragment, within amino acids 115-269, of human SOX10 protein. The exact sequence is proprietary.

Mouse

Monoclonal

rSOX10/1074

IgG1

Unconjugated

Protein A/G chromatography.

200 µg/ml

49-58 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

This monoclonal antibody is also available in a different formulation without BSA and Sodium Azide - Anti-SOX10 Antibody [rSOX10/1074] - BSA and Azide free (A253197).

DOM, Dominant megacolon mouse human homolog of, MGC15649, PCWH, SOX 10, SOX10_HUMAN, SRY (sex determining region Y) box 10, SRY box 10, SRY box containing gene 10, SRY related HMG box gene 10, Transcription factor SOX 10, Transcription factor SOX-10, WS2E, WS4, WS4C