Anti-Somatostatin Receptor 2 Antibody [SSTR2/7532] (A315668)

Anti-Somatostatin Receptor 2 Antibody [SSTR2/7532]

Mouse monoclonal [SSTR2/7532] antibody to Somatostatin Receptor 2.

SSTRs (for somatostatin receptors) represent a family of G protein-coupled receptors which mediate the diverse biological actions of somatostatin (SST). There are five distinct subtypes of SSTRs that bind two natural ligands, SST-14 and SST-28. SSTR2 gives rise to spliced variants, SSTR2A and 2B. SSTRs share common signaling pathways such as the ability to inhibit adenylyl cyclase via GTP binding proteins. Some of the subtypes are also coupled to tyrosine phosphatase (SSTR1,2), Ca2+ channels (SSTR2), Na+/H+ exchanger (SSTR1), PLA-2 (SSTR4), and MAP kinase (SSTR4). Individual target cells typically express more than one SSTR subtype and often all five isoforms. Subtypes of SSTR can form functional homo- and heterodimers.

Human Cerebrum and kidney. In lesser amounts in jejunum, colon and liver.

IHC: 1-2 µg/ml

Human

Recombinant fragment (around Amino Acids 300-500) of human SSTR2. The exact sequence is proprietary.

Mouse

Monoclonal

SSTR2/7532

lambda

Unconjugated

Protein A/G chromatography.

200 µg/ml

87 kDa / 148 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Somatostatin receptor type 2, SRIF-1, SRIF1, SS-2-R, SS2-R, SS2R, SSR2_HUMAN, SST2, SSTR2