Anti-SMNDC1 Antibody [PCRP-SMNDC1-1A9] (A248099)

Mouse monoclonal [PCRP-SMNDC1-1A9] antibody to SMNDC1 for Flow Cytometry and IF.

Alternative Formats and ConjugatesAlternative Formats

Freight Charges
Lead Time
4-6 Business Days
Telephone
+1 (314) 370-6046
Mon - Fri, 8am - 4pm AST
Email
orders@antibodies.com
Name
Anti-SMNDC1 Antibody [PCRP-SMNDC1-1A9]
Description
Mouse monoclonal [PCRP-SMNDC1-1A9] antibody to SMNDC1.
Specificity
SPF30 (survival of motor neuron-related-splicing factor 30), also known as SMNDC1 (survival motor neuron domain containing 1) or SMNR (SMN-related protein), is an essential splicing factor required for spliceosome assembly that belongs to the SMN family. It contains one Tudor domain with significant similarity to SMN (survival motor neuron) and is expressed in skeletal muscle, pancreas and heart, localizing to Cajal bodies and nuclear speckles. SPF30 plays an important role in spliceosome assembly and directly interacts with five U snRNPs. The loss of SPF30 causes spliceosome assembly to arrest at prespliceosomes (A complex). This supports a function for SPF30 in mediating the incorporation/recruitment of U4/U5/U6 tri-snRNP to the prespliceosome. In addition, the overexpression of SPF30 can lead to apoptosis.
Applications
Flow Cytometry, IF
Dilutions
Flow Cytometry: 1-2 µg/million cells, IF: 1-2 µg/ml
Reactivity
Human
Immunogen
Recombinant full-length human SMNDC1 protein.
Host
Mouse
Clonality
Monoclonal
Clone ID
PCRP-SMNDC1-1A9
Isotype
IgG2b
Conjugate

Unconjugated

Purification
Protein A/G chromatography.
Concentration
200 µg/ml
Molecular Weight
30 kDa
Product Form
Liquid
Formulation
Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
General Notes
This monoclonal antibody is also available in a different formulation without BSA and Sodium Azide - Anti-SMNDC1 Antibody [PCRP-SMNDC1-1A9] - BSA and Azide free (A251282).
Synonyms
30 kDa splicing factor SMNrp, MGC106917, MGC112663, SMN related protein, SMN-related protein, SMNR, SPF30, SPF30_HUMAN, Splicing factor 30, survival of motor neuron-related, Survival motor neuron domain containing 1, Survival motor neuron domain containing protein 1, Survival motor neuron domain-containing protein 1, Survival of motor neuron related splicing factor 30, Survival of motor neuron-related-splicing factor 30
Disclaimer
This product is for research use only. It is not intended for diagnostic or therapeutic use.
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