Anti-SARS-CoV-2 Spike Protein S2 Antibody (A283822)

Anti-SARS-CoV-2 Spike Protein S2 Antibody

Rabbit polyclonal antibody to SARS-CoV-2 Spike Protein S2.

This antibody recognises spike glycoprotein, also known as S glycoprotein, peplomer protein and E2.Human coronaviruses are pathogens that can cause severe respiratory tract infections. SARS-CoV-2 is a novel human coronavirus characterized in 2020, and causes "coronavirus disease 2019" or "COVID-19". The spike glycoproteins of coronaviruses are incorporated into the viral envelope and promote entry into cells. The spike glycoprotein of SARS-CoV-2 is comprised of two subunits called S1 and S2. The S1 protein binds to a receptor on human cells, and the transmembrane unit S2 helps fuse the viral membrane with a cellular membrane. Specifically, both SARS-CoV and SARS-CoV-2 spike proteins contain a receptor-binding domain (RBD) that recognize the same receptor, ACE2, on human cells. This antibody recognises the spike S2 protein of SARS-CoV-2.

WB, IF

IF: 10 µg/ml, WB: 1 µg/ml

Viral

A peptide corresponding to 16 amino acids near the center terminus of SARS-CoV-2 (COVID-19) Spike glycoprotein. The immunogen is located within 900-950 amino acids of SARS-CoV-2 (COVID-19) Spike protein.

Rabbit

Polyclonal

IgG

Unconjugated

1 mg/ml

Liquid

Supplied in Phosphate Buffered Saline with 0.02% Sodium Azide.

Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.

Rabbit anti SARS-CoV-2 spike protein S2 antibody recognizes spike glycoprotein, also known as S glycoprotein, peplomer protein and E2.Human coronaviruses are pathogens that can cause severe respiratory tract infections. SARS-CoV-2 is a novel human coronavirus characterized in 2020, and causes "coronavirus disease 2019" or "COVID-19" (Xu et al. 2020). The spike glycoproteins of coronaviruses are incorporated into the viral envelope and promote entry into cells (Walls et al. 2020). The spike glycoprotein of SARS-CoV-2 is comprised of two subunits called S1 and S2. The S1 protein binds to a receptor on human cells, and the transmembrane unit S2 helps fuse the viral membrane with a cellular membrane (Hoffmann et al. 2020). Specifically, both SARS-CoV and SARS-CoV-2 spike proteins contain a receptor-binding domain (RBD) that recognize the same receptor, ACE2, on human cells (Shang et al. 2020). This antibody recognizes the spike S2 protein of SARS-CoV-2.