Recombinant Anti-Sarcomeric alpha Actinin Antibody [ACTN2/7041R] (A315605)

Anti-Sarcomeric alpha Actinin Antibody [ACTN2/7041R]

Recombinant rabbit monoclonal [ACTN2/7041R] antibody to Sarcomeric alpha Actinin.

Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In non-muscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a muscle-specific, alpha actinin isoform that is expressed in both skeletal and cardiac muscles. Several transcript variants encoding different isoforms have been found for this gene.

Human skeletal or cardiac muscle.

IHC: 1-2 µg/ml

Human

A recombinant fragment (aa557-692) of human ACTN2 protein. The exact sequence is proprietary.

Rabbit

Monoclonal

ACTN2/7041R

kappa

Unconjugated

Protein A/G chromatography.

200 µg/ml

103 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Actin binding protein, Actinin alpha 2, ACTN 2, ACTN2, ACTN2_HUMAN, Alpha actinin 2, Alpha actinin skeletal muscle, Alpha actinin skeletal muscle isoform 2, Alpha-actinin skeletal muscle isoform 2, Alpha-actinin-2, CMD1AA, F actin cross linking protein, F-actin cross-linking protein