Schwann cells surround nerve fibres in the peripheral nervous system (PNS) and serve a variety of functions, including: providing structural support, conduction of nerve impulses along axons, clearing debris after axonal damage, and guiding axonal regeneration.
Schwann cells originate from neural crest cells which, during embryonic development, are further differentiated into Schwann cell precursors and immature Schwann cells. After the pro-myelin Schwann cell stage, the mature myelinating and non-myelinating Schwann cells are formed.
After peripheral nerve injury, mature Schwann cells in the distal stump will dedifferentiate into immature Schwann cells before differentiating into mature myelinating and non-myelinating Schwann cells after nerve regeneration.
The various developmental stages or wound repair phases of Schwann cells have distinct, but partially overlapping, markers. Use the buttons below to select Schwann cell markers based on their developmental stage.
This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional activator after forming a protein complex with other proteins. This protein acts as a nucleocytoplasmic shuttle protein and is important for neural crest and peripheral nervous system development. Mutations in this gene are associated with Waardenburg-Shah and Waardenburg-Hirschsprung disease. Target information from NCBI Gene ID: 6663.
| Product Name | Reactivity | Applications |
|---|---|---|
| Anti-SOX10 Antibody [SOX10/1074] (A250015) | Human, Mouse | WB, IHC-P |
| Recombinant Anti-SOX10 Antibody [SOX10/2311R] (A250019) | Human, Mouse | WB, IHC-P |
| Recombinant Anti-SOX10 Antibody [rSOX10/1074] (A250017) | Human, Mouse | WB, IHC-P |
| Anti-SOX10 Antibody (Biotin) (A52341) | Human, Monkey | ELISA, IHC, IP, WB |
| Anti-SOX10 Antibody (FITC) (A53138) | Human, Monkey | ELISA, IHC, IP, WB |
The protein encoded by this gene has been termed a 'growth' or 'plasticity' protein because it is expressed at high levels in neuronal growth cones during development and axonal regeneration. This protein is considered a crucial component of an effective regenerative response in the nervous system. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. Target information from NCBI Gene ID: 2596.
| Product Name | Reactivity | Applications |
|---|---|---|
| Anti-GAP43 Antibody [5E8] (A85392) | Human, Rat, Mouse | WB, ICC/IF, IHC |
| Anti-GAP43 Antibody [3H14] (A85393) | Human, Rat, Mouse | WB, ICC/IF, IHC |
| Anti-GAP43 Antibody (A85394) | Human, Horse, Cow, Porcine, Chicken, Rat, Mouse | WB, ICC/IF, IHC |
| Anti-GAP43 Antibody (A85292) | Human, Horse, Cow, Porcine, Chicken, Rat, Mouse | WB, ICC/IF, IHC |
| Anti-GAP43 (A35) Antibody (A27068) | Human, Mouse, Rat | WB, IHC, IF |
| Anti-GAP43 (phospho-S41) Antibody (A27737) | Human, Mouse, Rat | WB, IHC, IF |
This gene is specifically expressed in Schwann cells of the peripheral nervous system and encodes a type I transmembrane glycoprotein that is a major structural protein of the peripheral myelin sheath. The encoded protein contains a large hydrophobic extracellular domain and a smaller basic intracellular domain, which are essential for the formation and stabilization of the multilamellar structure of the compact myelin. Mutations in this gene are associated with autosomal dominant form of Charcot-Marie-Tooth disease type 1 (CMT1B) and other polyneuropathies, such as Dejerine-Sottas syndrome (DSS) and congenital hypomyelinating neuropathy (CHN). A recent study showed that two isoforms are produced from the same mRNA by use of alternative in-frame translation termination codons via a stop codon readthrough mechanism. Target information from NCBI Gene ID: 4359.
| Product Name | Reactivity | Applications |
|---|---|---|
| Anti-MPZ Antibody (A83515) | Rat | ELISA, WB |
| Anti-MPZ Antibody (A28371) | Human, Mouse, Rat | WB |
| Anti-Myelin protein P0 Antibody (A41768) | Human | WB |
Octamer-binding protein 6 (Oct6), also known as POU domain, class 3, transcription factor 1 (POU3F1). Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3'). Acts as a transcriptional activator when binding cooperatively with SOX4, SOX11, or SOX12 to gene promoters. Acts as a transcriptional repressor of myelin-specific genes. Target information from UniProt accession Q03052.
| Product Name | Reactivity | Applications |
|---|---|---|
| Anti-OCT6 Antibody (A97769) | Human, Mouse, Rat | WB, ELISA |
| Anti-POU3F1 Antibody (A45524) | Human, Mouse, Rat | IHC |
| Anti-POU3F1 Antibody (A84486) | Human | ELISA, WB |
| Anti-OCT6 Antibody [KT110] (A113) | Mouse | WB, ICC, IP |
| Anti-POU3F1 Antibody (A84999) | Human | ELISA, WB |
Transcription factor that forms a trimeric complex with OCT4 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206. Binds to the proximal enhancer region of NANOG. Critical for early embryogenesis and for embryonic stem cell pluripotency. Downstream SRRT target that mediates the promotion of neural stem cell self-renewal. Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation. May function as a switch in neuronal development. Target information from UniProt accession P48431.
| Product Name | Reactivity | Applications |
|---|---|---|
| Anti-SOX2 Antibody [SOX2/1791] (A250002) | Human, Mouse | ELISA, WB, IHC-P |
| Anti-SOX2 Antibody [SOX2/1792] (A250003) | Human, Mouse | ELISA, WB, IHC-P |
| Recombinant Anti-SOX2 Antibody [rSOX2/1792] (A250005) | Human, Mouse | ELISA, IHC-P |
| Anti-Sox2 Antibody (A24853) | Human, Mouse, Rat | WB |
| Anti-SOX2 Antibody (FITC) (A53537) | Human, Monkey, Mouse, Pig | ELISA, IMM, WB |
| Anti-SOX2 Antibody (Biotin) (A52642) | Human, Monkey, Mouse, Pig | ELISA, IP, WB |
The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21; however, this gene is located at 21q22.3. The S100B protein may function in Neurite extension, proliferation of melanoma cells, stimulation of Ca2+ fluxes, inhibition of PKC-mediated phosphorylation, astrocytosis and axonal proliferation, and inhibition of microtubule assembly. Chromosomal rearrangements and altered expression of this gene have been implicated in several neurological, neoplastic, and other types of diseases, including Alzheimer's disease, Down's syndrome, epilepsy, amyotrophic lateral sclerosis, melanoma, and type I diabetes. Target information from NCBI Gene ID: 6285.
| Product Name | Reactivity | Applications |
|---|---|---|
| Anti-S100A4 Antibody [S100A4/1481] (A249920) | Human, Mouse | FC, IF, WB, IHC-P |
| Anti-S100 α (A18) Antibody (A25344) | s100-alpha-a18-antibody-a25344 | WB, IHC, IF |
| Recombinant Anti-S100A4 Antibody [rS100A4/1481] (A249923) | Human, Mouse | FC, WB, IF, IHC-P |
| Anti-S100A4 Antibody (Biotin) [S100A4/1481] (A251228) | Human, Mouse | FC, WB, IF, IHC-P |
| Anti-S100A2 Antibody [CPTC-S100A2-2] (A249919) | Human | WB, FC, IF, IHC-P |
| Anti-S100 beta Antibody [S100B/1012] (A249936) | Human, Mouse, Rat, Bovine | FC, IF, WB, IHC-P |
Tumor necrosis factor receptor superfamily member 16, also known as NGFR. Low affinity receptor which can bind to NGF, BDNF, NTF3, and NTF4. Forms a heterodimeric receptor with SORCS2 that binds the precursor forms of NGF, BDNF and NTF3 with high affinity, and has much lower affinity for mature NGF and BDNF. Plays an important role in differentiation and survival of specific neuronal populations during development. Can mediate cell survival as well as cell death of neural cells. Target information from UniProt accession P08138.
| Product Name | Reactivity | Applications |
|---|---|---|
| Anti-CD271 Antibody [NGFR5] (A86284) | Human, Non-Human Primates, Feline, Rabbit, Ferret | FC, IP, WB, IHC-P, ICC |
| Anti-p75 NGF Receptor Antibody (A52726) | Human, Mouse, Rat | CM, ELISA, ICC, IF, IHC, IP, WB |
| Anti-p75 NGF Receptor Antibody [NGFR/1964] (A249503) | Human | IHC-P |
| Anti-TNR16 Antibody (A96023) | Human, Mouse, Rat | WB, IF, ELISA |
| Recombinant Anti-p75 NGF Receptor Antibody [NGFR/1997R] (A249504) | Human, Non-Human Primates | IHC-P |
| Anti-CD271 Antibody (APC) [NGFR5] (A86281) | Human, Non-Human Primates, Feline, Rabbit, Ferret | FC, IP, WB, IHC-P, ICC |
Also known as CD56, this gene encodes a cell adhesion protein which is a member of the immunoglobulin superfamily. The encoded protein is involved in cell-to-cell interactions as well as cell-matrix interactions during development and differentiation. The encoded protein has been shown to be involved in development of the nervous system, and for cells involved in the expansion of T cells and dendritic cells which play an important role in immune surveillance. Alternative splicing results in multiple transcript variants. Target information from NCBI Gene ID: 4684.
| Product Name | Reactivity | Applications |
|---|---|---|
| Anti-CD56 Antibody [MEM-188] (A85988) | Human, Non-Human Primates | FC, IP, IHC-P |
| Recombinant Anti-CD56 Antibody [RM315] (A121372) | Human | WB, IHC |
| Anti-CD56 Antibody (A82568) | Human | ELISA, WB, IHC |
| Anti-CD56 / NCAM Antibody (A54128) | Human, Mouse, Rat | ELISA, IHC, IP, WB |
| Anti-NCAM1 Antibody [NCAM1/795] (A249480) | Human, Rat | FC, IF, WB, IHC-P |
Also known as KROX20, this protein is a sequence-specific DNA-binding transcription factor. Plays a role in hindbrain segmentation by regulating the expression of a subset of homeobox containing genes and in Schwann cell myelination by regulating the expression of genes involved in the formation and maintenance of myelin. Binds to two EGR2-consensus sites EGR2A (5'-CTGTAGGAG-3') and EGR2B (5'-ATGTAGGTG-3') in the HOXB3 enhancer and promotes HOXB3 transcriptional activation. Binds to specific DNA sites located in the promoter region of HOXA4, HOXB2 and ERBB2. Regulates hindbrain segmentation by controlling the expression of Hox genes, such as HOXA4, HOXB3 and HOXB2, and thereby specifying odd and even rhombomeres. Promotes the expression of HOXB3 in the rhombomere r5 in the hindbrain. Regulates myelination in the peripheral nervous system after birth, possibly by regulating the expression of myelin proteins, such as MPZ, and by promoting the differentiation of Schwann cells. Target information from UniProt accession P11161.
| Product Name | Reactivity | Applications |
|---|---|---|
| Anti-EGR2 Antibody (A84367) | Human | ELISA, WB |
| Anti-EGR2 Antibody (A44171) | Human, Mouse, Rat | WB |
| Anti-EGR2 Antibody (A43635) | Human, Mouse, Rat | WB |
The classic group of MBP isoforms (isoform 4-isoform 14) are with PLP the most abundant protein components of the myelin membrane in the CNS. They have a role in both its formation and stabilization. The smaller isoforms might have an important role in remyelination of denuded axons in multiple sclerosis. The non-classic group of MBP isoforms (isoform 1-isoform 3/Golli-MBPs) may preferentially have a role in the early developing brain long before myelination, maybe as components of transcriptional complexes, and may also be involved in signaling pathways in T-cells and neural cells. Differential splicing events combined with optional post-translational modifications give a wide spectrum of isomers, with each of them potentially having a specialized function. Induces T-cell proliferation. Target information from UniProt accession P02686.
| Product Name | Reactivity | Applications |
|---|---|---|
| Anti-MBP Antibody [7G7] (A85322) | Human, Horse, Cow, Porcine, Chicken, Rat, Mouse | WB, IF/ICC, IHC |
| Anti-MBP Antibody [7D2] (A85329) | Human, Horse, Cow, Porcine, Chicken, Rat, Mouse | WB, IF/ICC, IHC |
| Anti-MBP Antibody (A85321) | Human, Horse, Cow, Porcine, Chicken, Rat, Mouse | WB, IF/ICC, IHC |
| Recombinant Anti-Myelin Basic Protein Antibody [MBP/4277R] (A249285) | Human | IHC-P |
| Recombinant Anti-Myelin Basic Protein Antibody [rMBP/4288] (A249284) | Human | WB, IHC-P |
| Anti-Myelin Basic Protein Antibody [ABT-MBP] (A95520) | Human | IHC |
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