Anti-RANKL Antibody [C01-2D2] (A279927)

$340

Mouse monoclonal [C01-2D2] antibody to RANKL for ELISA.

Freight Charges
Lead Time
4-6 Business Days
Telephone
+1 (314) 370-6046
Mon - Fri, 8am - 4pm AST
Email
orders@antibodies.com
Name
Anti-RANKL Antibody [C01-2D2]
Description
Mouse monoclonal [C01-2D2] antibody to RANKL.
Specificity
This antibody recognises CD254 also known as RANKL and TNFSF11. CD254 is a ~20 kDa glycoprotein, a member of the tumour necrosis factor (TNF) superfamily. CD254 is a ligand for the receptor activator of NF?B (RANK) and this interaction plays a role in osteoclastogenesis and bone resorption (Roodman 1999).CD254 is highly expressed by T lymphocytes and osteoblastic cells and it has been shown that the CD254/RANK interaction also plays a vital role in several immune related processes. These include lymph node and lymphocyte development , dendritic cell survival and T-cell activation. CD254 is also involved in apoptosis, through activation of the anti-apoptotic kinase AKT/PKB and the mTOR/S6K signalling pathway.
Applications
ELISA
Reactivity
Human
Immunogen
E. coli derived recombinant protein corresponding to amino acids 143-317 of human CD254.
Sequence
EKAMVDGSWLDLAKRSKLEAQPFAHLTINATDIPSGSHKVSLSSWYHDRGWAKISNMTFSNGKLIVNQDGFYYLYANICFRHHETSGDLATEYLQLMVYVTKTSIKIPSSHTLMKGGSTKYWSGNSEFHFYSINVGGFFKLRSGEEISIEVSNPSLLDPDQDATYFGAFKVRDID
Host
Mouse
Clonality
Monoclonal
Clone ID
C01-2D2
Isotype
IgG2b
Conjugate

Unconjugated

Purification
Protein G affinity chromatography of ascites.
Concentration
1 mg/ml
Product Form
Liquid
Formulation
Supplied in Phosphate Buffered Saline with <0.1% Sodium Azide.
Storage
Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.
General Notes
Mouse anti Human CD254, clone C01-2D2 recognizes CD254 also known as RANKL and TNFSF11. CD254 is a ~20 kDa glycoprotein, a member of the tumour necrosis factor (TNF) superfamily. CD254 is a ligand for the receptor activator of NF?B (RANK) and this interaction plays a role in osteoclastogenesis and bone resorption (Roodman 1999).CD254 is highly expressed by T lymphocytes and osteoblastic cells and it has been shown that the CD254/RANK interaction also plays a vital role in several immune related processes. These include lymph node and lymphocyte development (Kong et al. 1999), dendritic cell survival (Wong et al. 1997) and T-cell activation (Anderson et al. 1997). CD254 is also involved in apoptosis, through activation of the anti-apoptotic kinase AKT/PKB and the mTOR/S6K signalling pathway.
Synonyms
CD254, hRANKL2, ODF, OPGL, OPTB2, Osteoclast differentiation factor, Osteoprotegerin ligand, Receptor activator of nuclear factor kappa B ligand, Receptor activator of nuclear factor kappa-B ligand, sOdf, TNF related activation induced cytokine, TNF-related activation-induced cytokine, TNF11_HUMAN, TNFSF 11, Tnfsf11, TRANCE, Tumor necrosis factor (ligand) superfamily member 11, Tumor necrosis factor ligand superfamily member 11, Tumor necrosis factor ligand superfamily member 11, soluble form
Disclaimer
This product is for research use only. It is not intended for diagnostic or therapeutic use.
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