Anti-RAGE Antibody [B02-4G7] (A279728)

Anti-RAGE Antibody [B02-4G7]

Mouse monoclonal [B02-4G7] antibody to RAGE.

This antibody recognises Receptor for Advanced Glycosylation End products (RAGE), also known as advanced glycosylation end product-specific receptor. RAGE is a multi-ligand receptor belonging to the immunoglobulin receptor subfamily. It has many endogenous and exogenous ligands and upon binding of a ligand, RAGE can stimulate various signaling pathways including NF-?B, AP-1, CREB and STAT3. Triggering these pathways can then induce cytokine/chemokine transcription. This can be used to regulate the innate immune response, inflammation resolution, tissue homeostasis and tissue repair following injury. The purified Mouse anti Human RAGE antibody, clone B02-4G7 (MCA62676GA) can be used as a capture antibody in a sandwich ELISA with the biotinylated Mouse anti Human RAGE antibody, clone A09-5H8 (MCA6277B) as the detection antibody.

ELISA: 1 µg/ml

Human

E. coli derived recombinant human full length RAGE (Ala23-Pro404).

Mouse

Monoclonal

B02-4G7

IgG1

Unconjugated

1 mg/ml

Liquid

Supplied in Phosphate Buffered Saline with 0.09% Sodium Azide.

Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.

Mouse anti Human RAGE antibody, clone B02-4G7, recognizes Receptor for Advanced Glycosylation End products (RAGE), also known as advanced glycosylation end product-specific receptor. RAGE is a multi-ligand receptor belonging to the immunoglobulin receptor subfamily. It has many endogenous and exogenous ligands and upon binding of a ligand, RAGE can stimulate various signaling pathways including NF-?B, AP-1, CREB and STAT3. Triggering these pathways can then induce cytokine/chemokine transcription (Sorci et al. 2013). This can be used to regulate the innate immune response, inflammation resolution, tissue homeostasis and tissue repair following injury (Plotkin et al. 2019). The purified Mouse anti Human RAGE antibody, clone B02-4G7 (MCA62676GA) can be used as a capture antibody in a sandwich ELISA with the biotinylated Mouse anti Human RAGE antibody, clone A09-5H8 (MCA6277B) as the detection antibody.

Advanced glycosylation end product-specific receptor, Ager, MGC2235, RAGE_HUMAN, Receptor for advanced glycosylation end products