Recombinant Anti-PSGL-1 Antibody [PSGL1/8192R] (A315535)

Anti-PSGL-1 Antibody [PSGL1/8192R]

Recombinant rabbit monoclonal [PSGL1/8192R] antibody to PSGL-1.

CD162 glycoprotein functions as a high affinity counter-receptor for the cell adhesion molecules P-, E- and L- selectin expressed on myeloid cells and stimulated T lymphocytes. As such, this protein plays a critical role in leukocyte trafficking during inflammation by tethering of leukocytes to activated platelets or endothelia expressing selectins. This protein requires two post-translational modifications, tyrosine sulfation and the addition of the sialyl Lewis x tetrasaccharide (sLex) to its O-linked glycans, for its high-affinity binding activity. Aberrant expression of this gene and polymorphisms in this gene are associated with defects in the innate and adaptive immune response.

Human tonsil or spleen.

IHC: 1-2 µg/ml

Human

Recombinant full-length human SELPLG (CD162) protein.

Rabbit

Monoclonal

PSGL1/8192R

IgG

Unconjugated

Protein A/G chromatography.

200 µg/ml

43-120 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

CD 162, CD162, CD162 antigen, CLA, Cutaneous lymphocyte associated associated antigen, P selectin glycoprotein ligand 1, P selectin glycoprotein ligand 1 precursor, P-selectin glycoprotein ligand 1, PSGL 1, PSGL1, Selectin P ligand, SELPLG, SELPL_HUMAN