Anti-Prolactin Antibody [C01-2B2] (A279926)

$340

Mouse monoclonal [C01-2B2] antibody to Prolactin for ELISA.

Freight Charges
Lead Time
4-6 Business Days
Telephone
+1 (314) 370-6046
Mon - Fri, 8am - 4pm AST
Email
orders@antibodies.com
Name
Anti-Prolactin Antibody [C01-2B2]
Description
Mouse monoclonal [C01-2B2] antibody to Prolactin.
Specificity
This antibody recognises prolactin a peptide hormone expressed by many cell types including the pituitary gland, decidua, ovary, prostate, mammary gland, adipose tissue, brain and immune cells. Of the immune cells, prolactin is secreted by dentritic cells, thymocytes, T cells, B cells, monocytes and macrophages. Prolactin now has a reported >300 separate biological activities, since it was first discovered as a stimulator of crop milk in pigeons and a promotor of lactation in rabbits. In the immune system prolactin acts as a cytokine. In an example, prolactin is able to regulate innate and adaptive immune responses through the maturation of CD4- CD8- thymocytes to CD4+ CD8+ T cells via IL-2 receptor expression. Prolactin is also able to stimulate the development of antigen presenting cells expressing major histocompatibility complex class II. Where patients have an abnormally high level of circulating prolactin (hyperprolactinemia) this can result in the impairment of B cell clonal deletion, deregulation or receptor editing, as well as the diminishment of the threshold for B cell activation, promoting auto-reactivity. The purified Mouse anti Human prolactin antibody, clone C01-2B2 (MCA6200GA) can be used as a capture antibody in a sandwich ELISA with the biotinylated Mouse anti Human prolactin antibody, clone C03-3E9 (MCA6201B) as the detection antibody.
Applications
ELISA
Dilutions
ELISA: 1 µg/ml
Reactivity
Human
Immunogen
E. coli derived recombinant human prolactin (Leu29-Cys227).
Host
Mouse
Clonality
Monoclonal
Clone ID
C01-2B2
Isotype
IgG1
Conjugate

Unconjugated

Purification
Protein G affinity chromatography of tissue culture supernatant.
Concentration
1 mg/ml
Product Form
Liquid
Formulation
Supplied in Phosphate Buffered Saline with 0.09% Sodium Azide.
Storage
Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.
General Notes
Mouse anti Human prolactin antibody, clone C01-2B2, recognizes prolactin a peptide hormone expressed by many cell types including the pituitary gland, decidua, ovary, prostate, mammary gland, adipose tissue, brain and immune cells. Of the immune cells, prolactin is secreted by dentritic cells, thymocytes, T cells, B cells, monocytes and macrophages (Borba et al. 2018). Prolactin now has a reported >300 separate biological activities, since it was first discovered as a stimulator of crop milk in pigeons and a promotor of lactation in rabbits (Freeman et al. 2000). In the immune system prolactin acts as a cytokine. In an example, prolactin is able to regulate innate and adaptive immune responses through the maturation of CD4- CD8- thymocytes to CD4+ CD8+ T cells via IL-2 receptor expression. Prolactin is also able to stimulate the development of antigen presenting cells expressing major histocompatibility complex class II (Borba et al. 2018). Where patients have an abnormally high level of circulating prolactin (hyperprolactinemia) this can result in the impairment of B cell clonal deletion, deregulation or receptor editing, as well as the diminishment of the threshold for B cell activation, promoting auto-reactivity (Borba et al. 2018).The purified Mouse anti Human prolactin antibody, clone C01-2B2 (MCA6200GA) can be used as a capture antibody in a sandwich ELISA with the biotinylated Mouse anti Human prolactin antibody, clone C03-3E9 (MCA6201B) as the detection antibody.
Synonyms
AV290867, Decidual prolactin, GHA1, Growth hormone A1, Lactogenic Hormone , Luteotropic Hormone , Mammotropin, OTTMUSP00000000651, PRL, Prl1a1, Prol, Prolactin precursor , RATPRLSD1, RNPROL, RP23-351I6.2, RP3-404K8.1
Disclaimer
This product is for research use only. It is not intended for diagnostic or therapeutic use.
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