Recombinant Anti-Progesterone Receptor Antibody [PGR/8099R] (A315532)

Anti-Progesterone Receptor Antibody [PGR/8099R]

Recombinant rabbit monoclonal [PGR/8099R] antibody to Progesterone Receptor.

Progesterone is one of the central regulators of female reproduction. In breast development, progesterone is involved in the formation of lobular-alveolar structures and also affects differentiation in the breast by modulation of milk protein synthesis. The cellular effects of progesterone are mediated through progesterone receptors (PR). PR, a protein with 946 amino acids, is a ligand-activated transcription factor member of the steroid receptor super family of nuclear receptors. PR is predominantly expressed in female sex steroid responsive tissues such as the mammary gland, uterus and ovary but is also found in other tissues such as endocrine cells of the Langerhans islets. The estrogen receptor (ER) and PR status has been used for over 20 years as a predictor of breast carcinoma responsiveness to endocrine therapy and as a prognostic indicator for early recurrence.

Human breast carcinoma.

IHC: 1-2 µg/ml

Human

Recombinant fragment (around Amino Acids 1-200) of human PGR. The exact sequence is proprietary.

Rabbit

Monoclonal

PGR/8099R

kappa

Unconjugated

Protein A/G chromatography.

200 µg/ml

PR-A (81 kDa) / PR-B (116 kDa).

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

NR3C3, Nuclear receptor subfamily 3 group C member 3, PGR, PR, PRA, PRB, PRGR_HUMAN, Progestin receptor form A, Progestin receptor form B