Endoderm

Endoderm lineage markers are molecular indicators that help identify and study cells originating from the endoderm during embryonic development and in various tissues throughout life. The endoderm is one of the three primary germ layers in the developing embryo. It gives rise to a wide array of vital organs and tissues, including the respiratory and digestive systems, liver, pancreas, and thyroid gland. SOX17 (SRY-Box Transcription Factor 17) is a transcription factor that plays a key role in endoderm specification. It is amongst the earliest markers of endoderm commitment during embryogenesis and continues to be expressed in various endoderm-derived tissues such as the gut and liver. SOX17 regulates the expression of numerous genes involved in endoderm development. FOXA2 (Forkhead Box A2), also known as HNF3β, is another transcription factor that is highly expressed in endoderm and is crucial for liver, pancreas, and lung development. It helps establish the regional identity of endoderm-derived tissues and regulates the expression of genes necessary for their proper function. GATA4 and GATA6 are zinc finger transcription factors expressed in the endoderm that are important for heart and gut development. They are involved in the formation of the endodermal tube and contribute to the differentiation of cardiac and gastrointestinal tissues. HNF4α (Hepatocyte Nuclear Factor 4 Alpha) is a nuclear receptor that plays a key role in the development and function of the liver, pancreas, and intestines. It regulates the expression of genes associated with hepatic and intestinal differentiation and maintains the identity of these tissues. Several other transcription factors play key roles in endoderm-derived tissues. These include: 1) NKX2-1 (NK2 Homeobox 1), also known as TTF-1 (Thyroid Transcription Factor 1), a transcription factor that is essential for the development of the thyroid, lung, and ventral forebrain and a marker for these endoderm-derived structures; 2) PDX1 (Pancreatic and Duodenal Homeobox 1), a homeobox transcription factor critical for the development of the pancreas. It is expressed in pancreatic progenitor cells and plays a role in the differentiation of endoderm into pancreatic tissue; 3) CDX2 (Caudal-Type Homeobox 2), a homeobox transcription factor involved in the development of the intestinal epithelium. It helps establish the regional identity of the gut and is essential for proper gut development and function; 4) HNF1β (Hepatocyte Nuclear Factor 1 Beta), a transcription factor involved in the development of the kidney, liver, and pancreas. It regulates the expression of genes necessary for the formation and function of these endoderm-derived organs; 5) PAX8 (Paired Box 8), a transcription factor that plays a role in the development of the thyroid, kidney, and Mullerian ducts in females and a marker for these endoderm-derived structures; 6) AFP (Alpha-Fetoprotein), a glycoprotein that is primarily expressed in the developing liver and yolk sac endoderm. It is often used as a marker for hepatocyte differentiation and liver development. We provide a wide product catalogue of research reagents for studying endoderm lineage markers, including Vimentin antibodies, Albumin antibodies, FGF 23 antibodies, Apolipoprotein E ELISA Kits, and Glucagon ELISA Kits. Explore our full endoderm lineage markers product range below and discover more, for less.