Ectoderm lineage markers are cell surface or intracellular proteins that are expressed in cells derived from the ectoderm during embryonic development. The ectoderm is one of the three primary germ layers in early embryogenesis, giving rise to various tissues and structures in the body, including the nervous system, skin, hair, nails, and sensory organs. Nestin is an intermediate filament protein expressed in neural progenitor cells during early neural development. It is commonly used as a marker for neural stem cells and progenitors. Nestin-positive cells have the potential to differentiate into neurons, astrocytes, and oligodendrocytes. Sox1 (SRY-Box Transcription Factor 1) is a transcription factor that is expressed in early neural progenitor cells and plays a role in promoting neural development. It is often used as a marker for neural precursor cells and is involved in the maintenance of pluripotency in the developing nervous system. An additional transcription factor, Pax6 (Paired Box 6), plays a key role in eye development. It is expressed in the developing retina and lens, and it regulates the formation of various cell types within the eye, including retinal ganglion cells and photoreceptor cells. Several other markers are used to identify ectoderm-derived cells. These include: 1) neurofilament proteins, expressed in neurons and important for the structural integrity of axons. They are often used as markers for mature neurons; 2) Keratins, intermediate filament proteins commonly expressed in the epidermis and its derivatives, such as hair and nails. Keratinocytes, the primary cell type of the epidermis, express various keratins, including K14 and K19; 3) E-cadherin, a cell adhesion molecule expressed in the ectoderm-derived epithelial tissues. It is involved in cell-cell adhesion, particularly in the skin and the developing neural tube; 4) Sox9 (SRY-Box Transcription Factor 9), a transcription factor expressed in the ectodermal cells that give rise to the neural crest. It is essential for neural crest cell development and contributes to craniofacial structures and peripheral nervous system components; 5) N-cadherin (Cadherin 2), another cell adhesion molecule expressed in neural progenitor cells, and which plays a role in neural development. It is involved in cell migration and tissue morphogenesis during neural tube formation; 6) CD133 (Prominin-1), a cell surface protein expressed in various tissues, including the neural stem and progenitor cells within the brain. It is often used as a marker for neural stem cells and certain types of brain tumours; 7) β-tubulin III (Tuj1), a marker for differentiated neurons and involved in microtubule assembly in neurons. It is commonly used to identify neuronal populations within the developing nervous system; 8) Glial Fibrillary Acidic Protein (GFAP), an intermediate filament protein expressed in astrocytes, a type of glial cell in the central nervous system. It is used as a marker for astrocytic differentiation and for identifying mature astrocytes; 9) S100 Protein Family, a protein family often expressed in neural and glial cells. They play various roles in regulating cell function and are used as markers for specific cell types within the nervous system. We offer a comprehensive product range of research tools for studying ectoderm lineage markers, including Fibronectin antibodies, GATA3 antibodies, NSE antibodies, Fibronectin ELISA Kits, and Nestin ELISA Kits. Explore our full ectoderm lineage markers product range below and discover more, for less.