Myeloid progenitors are a subset of hematopoietic stem cells (HSCs) that produce various immune and non-immune cell types within the myeloid lineage. These cells play a central role in the innate immune response and tissue repair, contributing to the body's defence against infections and maintaining tissue homeostasis. Myeloid progenitors arise from hematopoietic stem cells (HSCs) in the bone marrow during haematopoiesis. They represent a lineage-committed population of cells dedicated to the development of various myeloid cell types, including granulocytes, monocytes, macrophages, dendritic cells, megakaryocytes, and osteoclasts. These cells are involved in a wide range of body functions, including phagocytosis, antigen presentation, platelet production, and tissue repair. Myeloid progenitors can further differentiate into granulocyte-macrophage progenitors (GMPs), which are committed to giving rise to granulocytes (neutrophils, eosinophils, basophils) and monocytes/macrophages. These cells are important for innate immune responses and inflammatory processes. Myeloid progenitors can also give rise to dendritic cell progenitors, which develop into dendritic cells. GM-CSF promotes the differentiation of myeloid progenitor cells into dendritic cell progenitors, inducing the commitment of myeloid progenitors to the DC lineage. An additional cytokine, FLT3-L, is also important for dendritic cell development. It acts on cells expressing the FLT3 receptor, found on myeloid progenitors, promoting their differentiation into dendritic cells the cells with a crucial role in antigen presentation and the initiation of adaptive immune responses. Some myeloid progenitors also differentiate into megakaryocyte-erythroid progenitors (MEPs), giving rise to two main lineages of blood cells: megakaryocytes (which produce platelets) and erythroid cells (which produce red blood cells). Megakaryocytes produce platelets essential for blood clotting and wound healing. Erythropoietin (EPO) is a critical factor in the development of MEPs into erythroid cells, promoting the survival, proliferation, and differentiation of erythroid progenitors. Conversely, thrombopoietin (TPO) is a cytokine that promotes the development of MEPs into megakaryocytes. TPO binds to its receptor, MPL (also known as c-MPL), on MEPs and promotes their differentiation into megakaryocytes. Myeloid progenitors can form colony-forming units (CFUs) when cultured in vitro. These CFUs represent clonal populations of myeloid cells derived from a single progenitor and are used for assessing the potential and differentiation capacity of myeloid progenitors. Several transcription factors are important for regulating myeloid progenitor development and include: 1) PU.1, regulator of myeloid cell development, essential for the commitment to the myeloid lineage and the regulation of genes involved in myelopoiesis; 2) C/EBPα and C/EBPβ, important for granulocyte and macrophage differentiation; 3) GATA-1 and GATA-2, involved in megakaryocyte development. Myeloid progenitors express various cell surface receptors that allow them to respond to specific cytokines and growth factors within the bone marrow microenvironment. For example, granulocyte colony-stimulating factor receptor (G-CSFR) is critical for granulocyte development. Functionally, myeloid cells derived from myeloid progenitors play a central role in the innate immune response. They are the first responders to infections and tissue damage, participating in processes such as phagocytosis, cytokine production, and antigen presentation. Dysregulation of myeloid progenitor development can lead to various haematological disorders, including myeloproliferative neoplasms, myelodysplastic syndromes, and acute myeloid leukaemia (AML). We offer a large product range of research reagents for investigating myeloid progenitors, including CD45 antibodies, CD4 antibodies, CD31 antibodies, SCF ELISA Kits, and CD62P ELISA Kits. Explore our full myeloid progenitors product range below and discover more, for less. Alternatively, you can explore our Monocytic Lineage, Neutrophil Lineage, and Dendritic Cell Lineage product ranges.