Endothelial progenitor cells (EPCs) are a subset of stem or progenitor cells that play an important role in vascular development, repair, and regeneration. They also contribute to angiogenesis, and are implicated in various physiological and pathological conditions, including wound healing, ischemic diseases, and tumour growth. To identify and characterize EPCs, specific markers expressed on the surface of these cells are employed. CD34 is a widely used marker for endothelial progenitor cells. It is a cell surface glycoprotein that is expressed on hematopoietic stem cells, as well as on EPCs. CD34+ EPCs are involved in angiogenesis and vascular repair. CD34 is often used in flow cytometry to identify and isolate EPCs from peripheral blood or bone marrow. CD133 (Prominin-1) is another cell surface marker for EPCs. It is a transmembrane glycoprotein associated with stem and progenitor cell populations in various tissues. CD133+ EPCs have been shown to contribute to neovascularization and endothelial repair. Like CD34, CD133 is frequently used in conjunction with other markers to isolate and characterize EPCs. VE-Cadherin (CD144) is a cell-cell adhesion molecule found on mature endothelial cells. However, it is also expressed on a subset of EPCs. VE-cadherin-expressing EPCs are thought to have a greater potential for incorporation into existing blood vessels. Kinase insert domain receptor (KDR), also known as VEGFR-2 (vascular endothelial growth factor receptor-2), is a receptor for VEGF-A, a key regulator of angiogenesis. KDR is expressed on mature endothelial cells, as well as on EPCs. It is involved in the signalling pathways that promote endothelial cell differentiation and proliferation. CD31 (also known as platelet endothelial cell adhesion molecule-1, PECAM-1) is a cell adhesion molecule found on the surface of endothelial cells. It is used as a marker for mature endothelial cells but is also expressed on a subset of EPCs. CD31 can help distinguish between circulating EPCs and fully differentiated endothelial cells. CXCR4 is a chemokine receptor that plays a role in stem cell homing and mobilization. It is expressed on EPCs and is involved in their recruitment to sites of vascular injury or angiogenesis. The interaction between CXCR4 and its ligand, SDF-1 (stromal cell-derived factor-1), is important for the process of EPC migration and homing. CD45 is a marker for hematopoietic cells, and its expression on EPCs is often used to distinguish them from mature endothelial cells. EPCs typically have lower CD45 expression compared to hematopoietic cells. CD146 (MCAM) is a cell adhesion molecule that is expressed on endothelial cells, pericytes, and a subset of EPCs. It plays a role in angiogenesis and cell migration. CD146-expressing EPCs are believed to have a higher angiogenic potential. CD90 (Thy-1) is a cell surface glycoprotein found on various cell types, including EPCs. It is associated with cell adhesion and signalling and is used as a marker for identifying EPCs in some studies. Finally, CD105 (Endoglin) is a co-receptor for transforming growth factor-beta (TGF-β) and is expressed on endothelial cells and a subset of EPCs. It plays a role in angiogenesis and vascular development. We offer a comprehensive product catalogue of research reagents for investigating endothelial markers, including CD34 antibodies, CD14 antibodies, Von Willebrand Factor antibodies, CD105 ELISA Kits, and Thrombomodulin ELISA Kits. Explore our full endothelial markers product range below and discover more, for less.