Krüppel factors, originally discovered in Drosophila, are a group of transcription factors that play important roles in embryonic development, particularly in determining body segment identity. Krüppel-like factors (KLFs) are involved in various biological processes in mammals, including cell differentiation, development, metabolism, and disease. Whilst Krüppel factors were initially identified in fruit flies, KLFs are a diverse family of transcription factors found in mammals, sharing functional similarities with the original Krüppel factors. KLFs share a common structural feature characterized by Cys2/His2 zinc finger motifs, which is essential for DNA binding. These zinc finger domains enable KLFs to recognize and bind to specific DNA sequences termed KLF response elements (KLFREs) or GC-rich motifs, often found in gene promoters or enhancers. Additionally, KLFs can interact with other transcription factors, coactivators, and corepressors, allowing them to modulate gene expression in a context-dependent manner. For example, KLF4 (Gut-enriched Krüppel-like Factor, GKLF) is involved in the differentiation of various cell types, including epithelial and stem cells. It plays a role in the development and maintenance of tissues such as the skin, gut, and lung. KLF4 is also known for its role in reprogramming somatic cells into induced pluripotent stem cells (iPSCs). Besides its role in epithelial differentiation, KLF4 is also involved in vascular development and the response to vascular injury. It participates in the regulation of endothelial cell function and may contribute to atherosclerosis development. KLF1 (Erythroid Krüppel-like Factor, EKLF) is essential for erythropoiesis, the process of red blood cell formation. It regulates the expression of globin genes and is critical for maintaining haemoglobin levels. Mutations in KLF1 can lead to various blood disorders such as Hereditary Persistence of Foetal Haemoglobin (HPFH), a condition in which individuals continue to produce foetal haemoglobin (HbF) into adulthood. KLF5 (Intestinal Krüppel-like Factor, IKLF) is expressed in the immune system and plays a role in the development and function of immune cells and involved in the regulation of proinflammatory genes in response to immune signals. KLF2 (Lung Krüppel-like Factor, LKLF) is a key regulator of endothelial cells and contributes to vascular development and function. It also plays a role in lipid metabolism and energy homeostasis. Similarly, KLF15 is associated with the regulation of glucose and lipid metabolism in the liver and adipose tissue. It influences insulin sensitivity and is implicated in metabolic disorders like diabetes. KLF6 acts as a tumour suppressor in prostate, lung, and colon cancer. It regulates cell cycle progression, apoptosis, and DNA repair, with mutations in KLF6 associated with increased cancer susceptibility. KLF9 (Basic Transcription Element-Binding Protein, BTEB1) has been implicated in both promoting and suppressing cancer, depending on the context. It can induce apoptosis and inhibit tumour growth in some cases whilst promoting cell proliferation in others. KLF8 is associated with EMT, a process involved in tissue remodelling and cancer metastasis, by regulating EMT-related genes. Finally, KLF5 is crucial for skin development and wound healing. It regulates keratinocyte proliferation and differentiation and contributes to the skin's barrier function. We offer a comprehensive product catalogue of research reagents for studying Krueppel like factors, including KLF4 antibodies, and HIC2 antibodies. Explore our full Krueppel like factors product range below and discover more, for less.