Nuclear signalling events play many important roles in cancer development and progression. Examples of nuclear signalling pathways include: 1) Nuclear Receptor signalling. Nuclear receptors are protein transcription factors that regulate gene expression by binding to specific DNA sequences. In cancer, abnormal activation or inactivation of nuclear receptors can promote tumour growth. For example, estrogen receptor signalling is critically involved in ER+ breast cancer, where estrogen promotes cell proliferation; 2) Wnt Signaling. Wnt signaling regulates cell proliferation, differentiation, and survival and dysregulation of Wnt signaling is commonly observed in cancer. Mutations in Wnt pathway components, such as β-catenin, lead to abnormal activation of downstream target genes, contributing to tumour initiation and progression; 3) Notch signalling. Notch signalling controls cell fate determination and tissue homeostasis. Altered Notch signalling is implicated in various cancers. Aberrant activation of Notch signalling can promote cell proliferation, inhibit apoptosis, and enhance cancer stem cell properties, leading to tumour growth; 4) Hedgehog signalling. The Hedgehog signalling pathway regulates cell growth and differentiation during embryonic development. Abnormal activation of Hedgehog signalling has been linked to several cancers, including basal cell carcinoma and medulloblastoma. Activation of Hedgehog pathway components, such as Smoothened, can promote tumour growth; 5) p53 signalling. p53 is a tumour suppressor protein involved in DNA repair, cell cycle arrest, and apoptosis. In cancer, mutations or loss of p53 function can lead to uncontrolled cell growth and genomic instability. p53 pathway dysregulation is observed in various cancer types; 6) NF-κB Signaling. NF-κB is a transcription factor that regulates immune responses, inflammation, and cell survival. Dysregulated NF-κB signalling is associated with cancer development and progression. Abnormal activation of NF-κB can promote tumour cell survival, angiogenesis, and metastasis; 7) DNA Damage Response. DNA damage response pathways monitor and repair DNA lesions to maintain genome integrity. Defects in DNA repair mechanisms, such as those involving BRCA1 and BRCA2 genes, increase the risk of developing certain cancers, particularly breast and ovarian cancers. We offer a wide product catalogue of research reagents for studying nuclear signaling, including Estrogen Receptor alpha antibodies, NF-kB p65 antibodies, Progesterone Receptor antibodies, NF-kB p65 ELISA Kits, and FOXO1A ELISA Kits. Explore our full nuclear signaling product range below and discover more, for less. Alternatively, you can explore our Nuclear Hormone Receptors, NFkB Pathway, and STAT Family product ranges.