EGF

The EGF (Epidermal Growth Factor) family of growth factors refers to a group of extracellular proteins that play critical roles in cell proliferation, differentiation, and tissue development. This family includes several members, each with distinct functions and signalling pathways. They include: 1) Epidermal Growth Factor (EGF), the prototypical member of the EGF family and the first growth factor discovered. It is primarily involved in the growth and development of the epidermis (outer layer of the skin) and various epithelial tissues. In normal cells EGF promotes cell division and migration, wound healing, and tissue repair; 2) Transforming Growth Factor-α (TGF-α) which binds to the same receptor and plays a crucial role in the development and maintenance of various organs and stimulates cell proliferation, migration, and differentiation; 3) Amphiregulin (AREG), involved in diverse biological processes, such as embryogenesis, tissue repair, and cancer progression. It also activates the EGF receptor and regulates cell growth, survival, and migration; 4) Betacellulin (BTC), which plays a crucial role in the development and maintenance of pancreatic β-cells responsible for insulin production; 5) Epiregulin (EREG), which is involved in tissue development, wound healing, and cancer progression. It also activates the EGF receptor and regulates cell proliferation, migration, and survival; 6) Heparin-binding EGF-like growth factor (HB-EGF), notable for its ability to bind to heparin and involved in diverse processes, such as tissue development, wound healing, and cardiovascular function; 7) Epigen, a relatively newly discovered member of the EGF family and predominantly expressed in the epidermis where it is involved in skin development and maintenance. The EGFR (Epidermal Growth Factor Receptor) superfamily, also known as the ErbB family, is a group of cell surface tyrosine kinase receptors that play key roles in cell signalling and regulation of various cellular processes. It is named after the first identified member, epidermal growth factor receptor (EGFR or ErbB1). The EGFR superfamily consists of four members: EGFR (ErbB1), ErbB2 (HER2/neu), ErbB3 (HER3), and ErbB4 (HER4). These receptors are characterized by their structure, which includes an extracellular ligand-binding domain, a transmembrane domain, and an intracellular tyrosine kinase domain. The activated EGFR superfamily receptors trigger various downstream signalling pathways, including the MAPK/ERK pathway, PI3K/Akt pathway, and JAK/STAT pathways. These pathways regulate important cellular processes such as cell proliferation, differentiation, survival, and migration. Dysregulation of the EGFR superfamily has been implicated in cancer. Overexpression, mutations, or amplification of EGFR and its family members can lead to aberrant signalling, uncontrolled cell growth, and tumour progression. Therefore, targeting EGFR superfamily receptors has been a significant focus in cancer therapy, with drugs such as EGFR inhibitors and monoclonal antibodies designed to inhibit their activity. We offer a wide product catalogue of research tools for investigating EGF, including ErbB 2 antibodies, ErbB 3 antibodies, EGF antibodies, EGF ELISA Kits, and ErbB 2 ELISA Kits. Explore our full EGF product range below and discover more, for less.