Anti-PD1 Antibody [EH12.2H7] (A280349)

Anti-PD1 Antibody [EH12.2H7]

Mouse monoclonal [EH12.2H7] antibody to PD1.

This antibody recognises CD279, a co-stimulatory molecule also known as programmed cell death-1 (PD-1).CD279 is a ~50-55 kDa membrane protein which is a member of the CD28 family, and functions as a regulator of T cell activation. It has two specific ligands; CD274 (PD-L1) and CD273 (PD-L2), and their interaction is key in the balance between stimulatory and inhibitory signals needed for effective immune responses to microbes and self-tolerance.CD279 is a marker for germinal center-associated T cells (Dorfman et al, 2006) and is inducibly expressed by T cells, B cells, NKT cells and monocytes upon activation.

Flow Cytometry, IHC-Fr

Human, Primate

Mouse

Monoclonal

EH12.2H7

IgG1

Unconjugated

Protein A affinity chromatography of tissue culture supernatant.

>95% (by SDS-PAGE).

Liquid

Supplied in Phosphate Buffered Saline with <0.1% Sodium Azide.

Store undiluted at 4°C. Do not freeze!

Mouse anti Human CD279 antibody, clone EH12.2H7 detects CD279, a co-stimulatory molecule also known as programmed cell death-1 (PD-1).CD279 is a ~50-55 kDa membrane protein which is a member of the CD28 family, and functions as a regulator of T cell activation (Fife and Pauken, 2011). It has two specific ligands; CD274 (PD-L1) and CD273 (PD-L2), and their interaction is key in the balance between stimulatory and inhibitory signals needed for effective immune responses to microbes and self-tolerance.CD279 is a marker for germinal center-associated T cells (Dorfman et al, 2006) and is inducibly expressed by T cells, B cells, NKT cells and monocytes upon activation.

CD279, CD279 antigen, hPD 1, hPD l, hPD-1, hSLE1, PD 1, PD-1, PDCD 1, PDCD1, PDCD1_HUMAN, Programmed cell death 1, Programmed cell death 1 protein, Programmed cell death protein 1, Protein PD 1, Protein PD-1, SLEB2, Systemic lupus erythematosus susceptibility 2