Recombinant Anti-PAX8 Antibody [PAX8/6848R] (A315478)

Anti-PAX8 Antibody [PAX8/6848R]

Recombinant rabbit monoclonal [PAX8/6848R] antibody to PAX8.

Recognizes a protein of 62kDa, identified as PAX8. It is a member of the paired box (PAX) family of transcription factors. This nuclear protein is involved in thyroid follicular cell development and expression of thyroid-specific genes. Mutations in this gene have been associated with thyroid dysgenesis, thyroid follicular carcinomas, and atypical thyroid adenomas. PAX-8 is expressed in the thyroid (and associated carcinomas), non-ciliated mucosal cells of the fallopian tubes, and simple ovarian inclusion cysts, but not normal ovarian surface epithelial cells. PAX-8 is expressed in a high percentage of ovarian serous, endometrioid, and clear cell carcinomas, but only rarely in primary ovarian mucinous adenocarcinomas. PAX-8 expression is reported in renal tubules as well as renal cell carcinoma, nephroblastoma, and seminoma. PAX-8 antibody may be used as an additional immunohistochemical marker for renal epithelial tumors.

HeLa or Raji cells. Human renal cell carcinoma (RCC) or ovarian serous carcinoma.

IHC: 1-2 µg/ml

Human

Recombinant fragment (around Amino Acids 150-300) of human PAX8. The exact sequence is proprietary.

Rabbit

Monoclonal

PAX8/6848R

kappa

Unconjugated

Protein A/G chromatography.

200 µg/ml

62 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

OTTHUMP00000158659, OTTHUMP00000158660, OTTHUMP00000203723, OTTHUMP00000203724, Paired box 8, Paired box gene 8, paired box homeotic gene 8, Paired box protein Pax 8, Paired box protein Pax-8, Paired domain gene 8, PAX 8, PAX8_HUMAN