Specificity
This antibody demonstrates a broad spectrum of cytokeratin reactivity. In normal tissues, this antibody is reactive with most epithelial types, including: bile ducts and hepatocytes in liver, bladder epithelium, breast ducts, bronchial epithelium, endometrium, intestinal epithelium of stomach, duodenum, ileum, colon, rectum, pancreas, ovarian epithelium, pancreatic acini, pituitary acini, pneumocytes, prostate, thyroid, skin (positive on the basal layer and negative on the superficial layers of squamous epithelium), and apocrine and sweat glands. In tumors, this antibody is reactive with most carcinomas, including breast, transitional cell (TCC), renal cell (RCC), lung adenocarcinoma, lung small cell, lung squamous cell, endometrial, prostate, ovarian, hepatocellular (HCC), colorectal CA, stomach and thyroid. This antibody is negative in certain normal tissues, including: brain, lymphocytes, all cells of hematolymphoid origin, muscle, brain, nerves, endothelium, and in certain tumors including: most melanomas, sarcomas, lymphomas, primitive neuroectodermal tumors (PNET) / Ewings, and gastrointestinal stromal tumors (GIST). Positivity has been seen on some dendritic cells in lymph nodes, some endothelia, and some muscle cells.