Recombinant Anti-pan Cytokeratin Antibody [KRTH/1576R + KRTL/1577R] (A251012)

Anti-pan Cytokeratin Antibody [KRTH/1576R + KRTL/1577R]

Recombinant rabbit monoclonal [KRTH/1576R + KRTL/1577R] antibody to pan Cytokeratin.

Twenty human keratins are resolved with two-dimensional gel electrophoresis into acidic (pI 6.0) subfamilies. This antibody cocktail recognizes acidic (Type I or LMW) and basic (Type II or HMW) cytokeratins, which 67kDa (CK1); 64kDa (CK3); 59kDa (CK4); 58kDa (CK5); 56kDa (CK6); 52kDa (CK8); 56.5kDa (CK10); 50kDa (CK14); 50kDa (CK15); 48kDa (CK16); 40kDa (CK19). Many studies have shown the usefulness of keratins as markers in cancer research and tumor diagnosis. It is a broad spectrum anti pan-cytokeratin antibody cocktail, which differentiates epithelial tumors from non-epithelial tumors e.g. squamous vs. adenocarcinoma of the lung, liver carcinoma, breast cancer, and esophageal cancer. It may be useful to characterize the source of various neoplasms and to study the distribution of cytokeratin containing cells in epithelia during normal development and during the development of epithelial neoplasms. This antibody stains cytokeratins present in normal and abnormal human tissues and has high sensitivity in the recognition of epithelial cells and carcinomas.

IHC-P: 0.25-0.5 µg/ml

Human

Recombinant full-length human KRT76 and KRT77 proteins.

Rabbit

Monoclonal

KRTH/1576R + KRTL/1577R

Unconjugated

Protein A/G chromatography.

200 µg/ml

40-67 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

This monoclonal antibody is also available in a different formulation without BSA and Sodium Azide - Anti-pan Cytokeratin Antibody [KRTH/1576R + KRTL/1577R] - BSA and Azide free (A254191).