Recombinant Anti-P Glycoprotein Antibody [MDR1/8986R] (A315432)

Anti-P Glycoprotein Antibody [MDR1/8986R]

Recombinant rabbit monoclonal [MDR1/8986R] antibody to P Glycoprotein.

Cells selected for resistance to a single cytotoxic drug may become crossresistant to a broad range of drugs with different structures and cellular targets. This phenomenon is called multiple drug resistance (MDR). MDR proteins (Mdrs) are members of a highly conserved superfamily of ATP-binding cassette transport proteins. Mdr-1 is an apical transmembrane protein that is an integral part of the blood-brain barrier and functions as a drug-transport pump transporting a variety of drugs from the brain back into the blood. The Mdr-1 gene is known as ABCB1 and is located on human chromosome 7q21.12. The mouse homolog of Mdr-1 is known as Mdr-3. Interestingly, a murine protein by the name of Mdr-1 exists and is encoded by the murine Abcb1b gene, but it is not homologous with human Mdr-1.

hPBL or Jurkat whole cell lysate. Human adrenal gland.

IHC: 1-2 µg/ml

Human

Recombinant fragment (around Amino Acids 500-700) of human ABCB1 protein. The exact sequence is proprietary.

Rabbit

Monoclonal

MDR1/8986R

kappa

Unconjugated

Protein A/G chromatography.

200 µg/ml

170 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

ABC20, ABCB1, ATP binding cassette, sub family B (MDR/TAP), member 1, ATP-binding cassette sub-family B member 1, CD243, CLCS, Colchicin sensitivity, Doxorubicin resistance, GP170, MDR1, MDR1_HUMAN, Multidrug resistance 1, Multidrug resistance protein 1, P glycoprotein 1, P gp, P-glycoprotein 1, PGY1