Anti-OTX2 Antibody [PCRP-OTX2-1E10] (A277729)

Anti-OTX2 Antibody [PCRP-OTX2-1E10]

Mouse monoclonal [PCRP-OTX2-1E10] antibody to OTX2.

Transcription factors OTX1 and OTX2, two murine homologs of the Drosophila orthodenticle (OTD), show a limited amino acid sequence divergence. OTX1 and OTX2 play an important role during early and later events required for proper brain development in that they are involved in the processes of induction, specification and regionalization of the brain. OTX1 is involved in corticogenesis, sensory organ development and pituitary functions, while OTX2 is necessary earlier in development, for the correct anterior neural plate specification and organization of the primitive streak. OTX2 is also required in the early specification of the neuroectoderm, which is destined to become the fore-midbrain, and both OTX1 and OTX2 co-operate in patterning the developing brain through a dosage-dependent mechanism. A molecular mechanism depending on a precise threshold of OTX proteins is necessary for the correct positioning of the isthmic region and for anterior brain patterning. The genes which encode OTX1 and OTX2 map to human chromosomes 2p13 and 14q22.3, respectively.

ELISA, IP, Flow Cytometry

IP: 1-2µg / 100-500µg proteins, Flow Cytometry: 1-2 µg/million cells

Human

This antibody is predicted to cross react with Chicken, Mouse, Rat, Xenopus, and Zebrafish.

Recombinant full-length human OTX2 protein.

Mouse

Monoclonal

PCRP-OTX2-1E10

Unconjugated

Protein A/G chromatography.

200 µg/ml

71.5 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

This monoclonal antibody is also available in a different formulation without BSA and Sodium Azide - Anti-OTX2 Antibody [PCRP-OTX2-1E10] - BSA and Azide free (A278317).

CPHD6, Homeobox protein OTX2, MCOPS 5, MCOPS5, MGC45000, Orthodenticle 2, Orthodenticle homeobox 2, Orthodenticle homolog 2, Orthodenticle homolog 2 (Drosophila), Orthodenticle2, Otx 2, OTX2_HUMAN