Anti-Occludin Antibody [rOCLN/8776] - BSA and Azide free
Description
Recombinant mouse monoclonal [rOCLN/8776] antibody to Occludin.
Specificity
Occludin is a tetraspan integral membrane protein in epithelial and endothelial tight junction (TJ) structures that can contain two extracellular loops. The protein exists in a variety of phosphorylated forms. Phosphorylation is involved in regulating both the localization and the function of Occludin. Expression of Occludin is upregulated by polyunsaturated fatty acids, increasing trans-endothelial cell resistance and reducing cellular permeability to large molecules. The level of Occludin varies greatly depending on tissue; in brain tissue, Occludin is highly expressed at cell-cell contact sites. Non-neural tissues show lower expression and discontinuous distribution. Up-regulation of epithelial Occludin may play a role in enhancing paracellular permeability and be related to the damage to the tight junction.
Applications
IHC-P
Positive Control
HepG2 cells. Human kidney.
Dilutions
IHC: 1-2 µg/ml
Reactivity
Human
Immunogen
Recombinant human Occludin fragment around Amino Acids 282-415. The exact sequence is proprietary.
Host
Mouse
Clonality
Monoclonal
Clone ID
rOCLN/8776
Isotype
IgG2b
Light Chains
kappa
Conjugate
Unconjugated
Purification
Protein A/G chromatography.
Concentration
1 mg/ml
Molecular Weight
60-82 kDa
Product Form
Liquid
Formulation
Supplied in 10mM Phosphate Buffered Saline; without Sodium Azide and carrier free.
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
This product is for research use only. It is not intended for diagnostic or therapeutic use.
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