Anti-Occludin Antibody [OCLN/2182] - BSA and Azide free (A316804)

$765

Mouse monoclonal [OCLN/2182] antibody to Occludin for IHC-P.

Alternative Formats and ConjugatesAlternative Formats

Freight Charges
Lead Time
4-6 Business Days
Telephone
+1 (314) 370-6046
Mon - Fri, 8am - 4pm AST
Email
orders@antibodies.com
Name
Anti-Occludin Antibody [OCLN/2182] - BSA and Azide free
Description
Mouse monoclonal [OCLN/2182] antibody to Occludin.
Specificity
Occludin is a tetraspan integral membrane protein in epithelial and endothelial tight junction (TJ) structures that can contain two extracellular loops. The protein exists in a variety of phosphorylated forms. Phosphorylation is involved in regulating both the localization and the function of Occludin. Expression of Occludin is upregulated by polyunsaturated fatty acids, increasing trans-endothelial cell resistance and reducing cellular permeability to large molecules. The level of Occludin varies greatly depending on tissue; in brain tissue, Occludin is highly expressed at cell-cell contact sites. Non-neural tissues show lower expression and discontinuous distribution. Up-regulation of epithelial Occludin may play a role in enhancing paracellular permeability and be related to the damage to the tight junction.
Applications
IHC-P
Positive Control
HepG2 cells. Human kidney.
Dilutions
IHC: 1-2 µg/ml
Reactivity
Human
Immunogen
Recombinant human Occludin fragment around Amino Acids 282-415. The exact sequence is proprietary.
Host
Mouse
Clonality
Monoclonal
Clone ID
OCLN/2182
Isotype
IgG1
Light Chains
kappa
Conjugate

Unconjugated

Purification
Protein A/G chromatography.
Concentration
1 mg/ml
Molecular Weight
60-82 kDa
Product Form
Liquid
Formulation
Supplied in 10mM Phosphate Buffered Saline; without Sodium Azide and carrier free.
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Synonyms
BLCPMG, FLJ08163, FLJ18079, FLJ77961, FLJ94056, MGC34277, Ocln, OCLN_HUMAN, Phosphatase 1 regulatory subunit 115, PPP1R115, PTORCH1, Tight junction protein occludin
Disclaimer
This product is for research use only. It is not intended for diagnostic or therapeutic use.
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