Anti-NRF1 Antibody [NRF1/2608] (A249532)

Anti-NRF1 Antibody [NRF1/2608]

Mouse monoclonal [NRF1/2608] antibody to NRF1.

The NF-E2 DNA binding protein is composed of two subunits, p45 and MafK, and it regulates expression of globin genes in developing erythroid cells through interaction with Maf recognition elements (MAREs). A family of NF-E2 related proteins, which are collectively known as the Cap 'n' collar (CNC) family and include Nrf1 (also designated TCF11), Nrf2 and Nrf3, are bZIP transcription factors that heterodimerize with Maf proteins to bind MARE sequences. The Nrf proteins also bind the antioxidant response element (ARE) and are implicated in the regulation of detoxification enzymes and the oxidative stress response. They do so by heterodimerizing with Jun family members (c-Jun, JunB and JunD) to activate gene expression, specifically the detoxifying enzyme, NQO1. Nrf2 is widely expressed and is thought to translocate to the nucleus after treatment with xenobiotics and antioxidants, which stimulate its release from a repressor protein Keap1. Nrf3 is highly expressed in placenta, B cells and monocytes.

IHC-P: 1-2 µg/ml

Human

Recombinant full-length human NRF1 protein.

Mouse

Monoclonal

NRF1/2608

IgG1

Unconjugated

Protein A/G chromatography.

200 µg/ml

30 kDa (bZIP region) / 65-120 kDa (glycosylated)

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

This monoclonal antibody is also available in a different formulation without BSA and Sodium Azide - Anti-NRF1 Antibody [NRF1/2608] - BSA and Azide free (A252712).

alpha pal, alpha palindromic binding protein, Alpha palindromic-binding protein, Alpha-pal, locus control region factor 1, NFE2 related factor 1, NRF-1, NRF1_HUMAN, Nuclear respiratory factor 1