Anti-NKG2D Antibody [1D11] - BSA and Azide free (A279091)

Anti-NKG2D Antibody [1D11] - BSA and Azide free

Mouse monoclonal [1D11] antibody to NKG2D.

This antibody recognises CD314, also known as natural killer receptor G2 (NKG2D) and as killer cell lectin-like receptor subfamily K, member 1 (KLRK1). CD314 is a C-type lectin-like activating receptor which is expressed on most natural killer (NK) cells, CD8 T cells and gamma delta T cells. CD314 forms homodimers that signal through an associated DAP10 adaptor protein. Ligands of CD314 include MICA, MICB and UL16 binding protein (ULBP), which are inducibly expressed. Ligand binding toCD314 results in NK cell activation and potent co-stimulation of effector T cells. Mouse anti Human CD314 antibody, clone 1D11 is reported to inhibit T cell recognition of MICA.

IHC-Fr, Flow Cytometry, IP, Functional Assays

Flow Cytometry: 1:50 - 1:200, Use 10µl of the suggested working dilution to label 10⁶ cells in 100µl

Human

NKL cells.

Mouse

Monoclonal

1D11

IgG1

1 mg/ml

Liquid

Supplied in Phosphate Buffered Saline.

Store at -20°C only. Storage in frost free freezers is not recommended. Avoid freeze-thaw cycles. Should this product contain a precipitate we recommend microcentrifugation before use.

Mouse anti Human CD314 antibody, clone 1D11 recognizes CD314, also known as natural killer receptor G2 (NKG2D) and as killer cell lectin-like receptor subfamily K, member 1 (KLRK1). CD314 is a C-type lectin-like activating receptor which is expressed on most natural killer (NK) cells, CD8 T cells and gamma delta T cells. CD314 forms homodimers that signal through an associated DAP10 adaptor protein. Ligands of CD314 include MICA, MICB and UL16 binding protein (ULBP), which are inducibly expressed. Ligand binding toCD314 results in NK cell activation and potent co-stimulation of effector T cells. Mouse anti Human CD314 antibody, clone 1D11 is reported to inhibit T cell recognition of MICA (Bauer et al. 1999).

CD314, D12S2489E, Killer cell lectin-like receptor subfamily K member 1, KLRK1, NK cell receptor D, NKG2-D type II integral membrane protein, NKG2-D-activating NK receptor