Astrocytes are star-shaped glial cells found in the central nervous system. They serve a variety of functions, including: maintenance of extracellular ion balance, provision of nutrients (such as lactate) to neurons, supporting repair & regeneration after CNS damage, and modulation of synaptic transmission. Astrocytes have been identified as being dysfunctional in some neurodegenerative diseases, including: Huntington’s disease, Parkinson’s disease, Alzheimer’s disease, and amyotrophic lateral sclerosis.
GFAP, a class-III intermediate filament, is a cell-specific marker that, during the development of the central nervous system, distinguishes astrocytes from other glial cells. Target information from UniProt accession P14136.
| Product Name | Reactivity | Applications |
|---|---|---|
| Anti-GFAP Antibody (A85419) | Human, Horse, Cow, Porcine, Chicken, Rat, Mouse | WB, ICC/IF, IHC |
| Anti-GFAP Antibody [GA-5] (A85508) | Human, Porcine, Rat | IP, WB, IHC-P, ICC |
| Anti-GFAP Antibody (A85307) | Human, Horse, Cow, Porcine, Chicken, Rat, Mouse | WB, ICC/IF, IHC |
| Anti-GFAP Antibody [2A5] (A104314) | Human, Rat, Mouse, Bovine, Porcine | WB, ICC/IF, IHC |
| Recombinant Anti-GFAP Antibody [rASTRO/789] (A248711) | Human, Mouse, Rat, Bovine, Porcine, Rabbit, Chicken | FC, WB, IHC-P |
| Anti-GFAP Antibody (FITC) (A54231) | Human, Mouse, Rat | ELISA, IMM, WB |
Transports L-glutamate and also L- and D-aspartate. Essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft. Acts as a symport by cotransporting sodium. Target information from UniProt accession P43003.
| Product Name | Reactivity | Applications |
|---|---|---|
| Anti-EAAT1 Antibody (A54665) | Human, Monkey, Mouse, Rat | ELISA, IHC, IP, WB |
| Anti-EAAT1 Antibody (A101114) | Human | WB, ELISA |
| Anti-SLC1A3 Antibody (A42560) | Human | WB |
| Anti-EAAT1 Antibody (Biotin) (A52937) | Human, Monkey, Mouse, Rat | ELISA, IHC, IP, WB |
| Anti-EAAT1 Antibody (FITC) (A53833) | Human, Monkey, Mouse, Rat | ELISA, IHC, IP, WB |
| Anti-SLC1A3 Antibody (A82700) | Human | ELISA, WB |
Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate. Functions as a symporter that transports one amino acid molecule together with two or three Na+ ions and one proton, in parallel with the counter-transport of one K+ ion. Mediates Cl- flux that is not coupled to amino acid transport; this avoids the accumulation of negative charges due to aspartate and Na+ symport. Essential for the rapid removal of released glutamate from the synaptic cleft, and for terminating the postsynaptic action of glutamate. Target information from UniProt accession P43004.
| Product Name | Reactivity | Applications |
|---|---|---|
| Anti-EAAT2 Antibody (A54765) | Human, Mouse, Rat | ELISA, WB |
| Anti-EAAT2 Antibody (Biotin) (A53031) | Human, Mouse, Rat | ELISA, WB |
| Anti-EAAT2 Antibody (FITC) (A53928) | Human, Mouse, Rat | ELISA, WB |
Glutamine synthetase that catalyzes the ATP-dependent conversion of glutamate and ammonia to glutamine. Its role depends on tissue localization: in the brain, it regulates the levels of toxic ammonia and converts neurotoxic glutamate to harmless glutamine, whereas in the liver, it is one of the enzymes responsible for the removal of ammonia. Essential for proliferation of fetal skin fibroblasts. Independently of its glutamine synthetase activity, required for endothelial cell migration during vascular development: acts by regulating membrane localization and activation of the GTPase RHOJ, possibly by promoting RHOJ palmitoylation. May act as a palmitoyltransferase for RHOJ: able to autopalmitoylate and then transfer the palmitoyl group to RHOJ. Target information from UniProt accession P15104.
| Product Name | Reactivity | Applications |
|---|---|---|
| Anti-Glutamine Synthetase Antibody (A101718) | Plant | WB, ELISA |
| Anti-GLUL Antibody (A35556) | Human, Mouse, Rat | WB, IHC, IF |
| Anti-GLUL Antibody (A30328) | Human, Mouse, Rat | WB, IHC, IF |
| Anti-Gl Syn Antibody (A96889) | Human, Mouse, Rat | WB, ELISA |
| Anti-GLUL Antibody (A27984) | Human, Mouse, Rat | WB |
| Anti-Glutamine Synthetase Antibody (A40952) | Human, Mouse, Rat | WB |
Weakly binds calcium but binds zinc very tightly - distinct binding sites with different affinities exist for both ions on each monomer. Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites. Binds to and initiates the activation of STK38 by releasing autoinhibitory intramolecular interactions within the kinase. Interaction with AGER after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling. Could assist ATAD3A cytoplasmic processing, preventing aggregation and favoring mitochondrial localization. May mediate calcium-dependent regulation on many physiological processes by interacting with other proteins, such as TPR-containing proteins, and modulating their activity. Target information from UniProt accession P04271.
| Product Name | Reactivity | Applications |
|---|---|---|
| Recombinant Anti-S100 beta Antibody [rS100B/1896] (A249938) | Human, Mouse, Rat, Bovine | WB, IHC-P |
| Anti-S100 beta Antibody [S100B/1012] (A249936) | Human, Mouse, Rat, Bovine | FC, IF, WB, IHC-P |
| Anti-S100 beta Antibody [4C4.9] (A249934) | Human, Mouse, Rat, Bovine | FC, IF, WB, IHC-P |
| Recombinant Anti-S100 beta Antibody [RM304] (A121379) | Human | WB, IHC |
| Anti-S100 beta Antibody (A249941) | Human, Mouse, Rat, Bovine | IHC-P |
| Anti-S100 beta Antibody (CF® 488) [S100B/1012] (A251210) | Human, Mouse, Rat, Bovine | FC, IF |
The protein encoded by this gene catalyzes the conversion of 10-formyltetrahydrofolate, nicotinamide adenine dinucleotide phosphate (NADP+), and water to tetrahydrofolate, NADPH, and carbon dioxide. The encoded protein belongs to the aldehyde dehydrogenase family. Loss of function or expression of this gene is associated with decreased apoptosis, increased cell motility, and cancer progression. There is an antisense transcript that overlaps on the opposite strand with this gene locus. Alternative splicing results in multiple transcript variants. Target information from NCBI Gene ID: 10840.
| Product Name | Reactivity | Applications |
|---|---|---|
| Anti-Aldehyde Dehydrogenase H1L1 Antibody [4A12] (A85315) | Human, Horse, Cow, Porcine, Chicken, Rat, Mouse | WB, ICC/IF, IHC |
| Anti-Aldehyde Dehydrogenase H1L1 Antibody (A85310) | Human, Horse, Cow, Porcine, Chicken, Rat, Mouse | WB, ICC/IF, IHC |
| Anti-ALDH1L1 Antibody (A36256) | Human, Mouse | WB, IHC |
| Anti-ALDH1L1 Antibody (A31850) | Human, Mouse, Rat | WB, IHC |
| Anti-Aldehyde Dehydrogenase H1L1 Antibody [4A12] (A85313) | Human, Horse, Cow, Porcine, Chicken, Rat, Mouse | WB, ICC/IF, IHC |
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