Anti-Neurofilament Heavy Polypeptide Antibody [NF421 + NFL/736] (A250886)

Anti-Neurofilament Heavy Polypeptide Antibody [NF421 + NFL/736]

Mouse monoclonal [NF421 + NFL/736] antibody to Neurofilament Heavy Polypeptide.

This antibody reacts with a 200kDa and 68kDa protein, identified as heavy and light sub-units of neurofilaments (NF-H NF-L). Neurofilaments make up the main structural elements of axons and dendrites and are found in neurons, peripheral nerves, and sympathetic ganglion cells. Neurofilaments consist of three major subunits with molecular weights of 68kDa (NF-L), 160kDa (NF-M) and 200kDa (NF-H). Anti-neurofilament stains a number of neural, neuroendocrine, and endocrine tumors. Neuromas, ganglioneuromas, gangliogliomas, ganglioneuroblastomas, and neuroblastomas stain positively for anti-neurofilament. Neurofilaments are also present in paragangliomas as well as adrenal and extra-adrenal pheochromocytomas. Carcinoids, neuroendocrine carcinomas of the skin, and oat cell carcinomas of the lung also express neurofilament.

Flow Cytometry, IF, IHC-P

Flow Cytometry: 1-2 µg/million cells, IF: 1-2 µg/ml, IHC-P: 0.5-1 µg/ml

Human, Mouse, Rat, Chicken, Porcine

Recombinant human Neurofilament protein.

Mouse

Oligoclonal

NF421 + NFL/736

IgG1, kappa + IgG1, kappa

200 µg/ml

200 kDa / 68 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

200 kDa neurofilament protein, CMT2CC, Nefh, Neurofilament heavy polypeptide 200kDa, Neurofilament triplet H protein, NF H, NF-H, NFH, NFH_HUMAN