Anti-Myelin PLP Antibody [plpc1] (A281568)

Anti-Myelin PLP Antibody [plpc1]

Mouse monoclonal [plpc1] antibody to Myelin PLP.

This antibody recognises myelin proteolipid protein (PLP) in many mammalian species. Clone plpc1 also recognises the alternative PLP splice variant lacking part of the cytoplasmic domain (amino acids 117-151), known as DM20. PLP encodes the major protein components of compact CNS myelin and mutations in the PLP gene can lead to severe dysmyelinating disease. Mouse anti myelin proteolipid protein, clone plpc1 has proved a useful immunohistochemical tool for the study of central nervous system injury in patients with multiple sclerosis (Seewan et al. 2011, Huizinga et al. 2011)

WB, IHC-P, IF, Flow Cytometry, IHC-Fr

Bovine, Human, Tenerife lizard (Gallotia galloti)

Synthetic peptide sequence GRGTKF corresponding to C terminal region of myelin proteolipid protein.

GRGTKF

Mouse

Monoclonal

plpc1

IgG2a

Unconjugated

1 mg/ml

Liquid

Supplied in Phosphate Buffered Saline with <0.1% Sodium Azide.

Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.

Mouse anti myelin proteolipid protein antibody, clone plpc1 recognizes myelin proteolipid protein (PLP) in many mammalian species (Stoffel et al. 1985). Clone plpc1 also recognizes the alternative PLP splice variant lacking part of the cytoplasmic domain (amino acids 117-151), known as DM20 (Simons et al. 1987) .PLP encodes the major protein components of compact CNS myelin and mutations in the PLP gene can lead to severe dysmyelinating disease (Hudson et al. 1989).Mouse anti myelin proteolipid protein, clone plpc1 has proved a useful immunohistochemical tool for the study of central nervous system injury in patients with multiple sclerosis (Seewan et al. 2011, Huizinga et al. 2011)

HLD1, Lipophilin, Major myelin proteolipid protein, MMPL, Myelin proteolipid protein, MYPR_HUMAN, PLP, PLP 1, PLP/DM20, PLP1, PMD, Proteolipid protein 1, SPG2