Anti-MUC16 Antibody [MUC16/1860] - BSA and Azide free (A253804)

Name: Anti-MUC16 Antibody [MUC16/1860] - BSA and Azide free
Brand: Antibodies.com
SKU: A253804
Price: 525.0 USD
Availability: InStock

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$525

Mouse monoclonal [MUC16/1860] antibody to MUC16 for IHC-P.

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Alternative Formats and ConjugatesAlternative Formats

Unconjugated

Delivery

Freight Charges

$40 to United States

Lead Time

4-6 Business Days

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Telephone

+1 (314) 370-6046

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Specifications

Name

Anti-MUC16 Antibody [MUC16/1860] - BSA and Azide free

Description

Mouse monoclonal [MUC16/1860] antibody to MUC16.

Specificity

The mucins are a family of highly glycosylated, secreted proteins with a basic structure consisting of a variable number of tandem repeats (VNTRs). Membrane-associated and secretory Mucins are high molecular weight glycoproteins of the glycocalyx (polysaccharide biofilm) that protects mucosal epithelium from particulate matter and microorganisms. Epithelial Mucins are large, secreted and cell surface glycoproteins crucial for adhesion modulation, signaling and epithelial cell protection. The number of repeats is highly polymorphic and varies among different alleles. The Mucin family consists of Mucins 1-4, Mucin 5 (AC and B), Mucins 6-8, Mucins 11-13 and Mucins 15-17. The Mucin 16 protein (also commonly referred to as CA125), encoded for by the gene MUC16, is a very high molecular weight tumor antigen consisting of three domains: a carboxy terminal domain, an extracellular domain and an amino terminal domain. Mucin 16, an ovarian cancer-associated antigen, is used as a marker to monitor the progress of epithelial ovarian cancer. It is a hydrophilic membrane-associated protein that may be involved in vitamin A functions.

Applications

IHC-P

Dilutions

IHC-P: 1-2 µg/ml

Reactivity

Human

Immunogen

Native full-length human MUC16 protein, purified from human ovarian carcinoma.

Host

Mouse

Clonality

Monoclonal

Clone ID

MUC16/1860

Isotype

IgG1

Light Chains

kappa

Conjugate

Unconjugated

Purification

Protein A/G chromatography.

Concentration

1 mg/ml

Molecular Weight

>2,000 kDa

Product Form

Liquid

Formulation

Supplied in 10mM Phosphate Buffered Saline; without Sodium Azide and carrier free.

Storage

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

General Notes

This monoclonal antibody is also available in a different formulation with BSA and Sodium Azide - Anti-MUC16 Antibody [MUC16/1860] (A250624).

Synonyms

CA 125, CA-125, CA125, CA125 ovarian cancer antigen, Cancer antigen 125, FLJ14303, MUC 16, MUC-16, MUC16_HUMAN, Mucin 16, Mucin 16 cell surface associated, Mucin-16, Mucin16, Ovarian cancer related tumor marker CA125, Ovarian cancer-related tumor marker CA125, Ovarian carcinoma antigen CA125

Isotype Controls

Suitable Secondaries

See all Anti-Mouse IgG Secondaries →

Disclaimer

This product is for research use only. It is not intended for diagnostic or therapeutic use.

Scientific Validation Data (2)

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Figure 1: Immunohistochemistry - Anti-MUC16 Antibody [MUC16/1860] - BSA and Azide free (A253804)

Immunohistochemical analysis of formalin-fixed, paraffin-embedded human ovarian carcinoma using Anti-MUC16 Antibody [MUC16/1860].

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Figure 2: SDS-PAGE - Anti-MUC16 Antibody [MUC16/1860] - BSA and Azide free (A253804)

SDS-PAGE analysis of Anti-MUC16 Antibody [MUC16/1860] under non-reduced and reduced conditions; showing intact IgG and intact heavy and light chains, respectively. SDS-PAGE analysis confirms the integrity and purity of the antibody.

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